COTTON, P.B., ROSENBERG, M.T., WALDRAM, R.P.L. & AXON, A.T.R. (1973) Early endoscopy of oesophagus, stomach and duodenal bulb in patients with haematemesis and melaena. British Medical Journal, 2, 505. FORBES, C.D., BARR, R.D., PRENTICE, C.R.M. & DOUGLAS, A.S. (1973) Gastrointestinal bleeding in haemophilia. Quarterly Journal of Medicine, N.S., XLII, 503. MARTEL, W., SCHOLTENS, P.A. & LIM, L.W....

Haemophilia and inherited bleeding disorders in newborns and their carrier mothers pose unique challenges. The pattern of bleeding and the causes and risk factors for bleeding are decidedly different than an older child or an adult with haemophilia/inherited bleeding disorder. This document outlines the needs for further research and education, summarizes the state of the art background informa...

1.0 GENERAL RECOMMENDATIONS Where guidance states this is recommended practice or text is given in italics then this should be followed to ensure quality of service. It is recommended that genetic testing for haemophilia in the UK should be performed in a member laboratory of the UKHCDO Haemophilia Genetics Laboratory Network. This is a consortium of laboratories, within Comprehensive Care Haem...

BACKGROUND AND OBJECTIVES Health Related Quality of Life (HRQoL) is an important health outcome measure in haemophilia. The aim of this study was to assess the psychometric properties of the Greek version of Haem-A-QoL, a disease-specific questionnaire for haemophiliacs. METHODS Haem-A-QoL and SF-36 were administered to 118 adult haemophilia patients. Hypothesized scale structure, internal co...

BACKGROUND Problems concerning treatment of patients with haemophilia are long-term and exist even in the present days. Thanks to interdisciplinary complex therapy the results of treatment are constantly better than many years ago. AIM The goal of this study is to analyse the current state of management of haemophilia and to suggest a comprehensive concept of rational and effective rehabilita...

Medicinal products of biological origin still carry a specific iatrogenic risk, mainly because of their starting material, mode of preparation and variability. Careful postmarketing surveillance systems are therefore necessary. To assess the long-term safety of haemophilia treatment with plasma-derived and recombinant clotting factor products, a cohort study was set up in France in 1994. Partic...

Type and quantity of replacement treatment, together with haematological and immunological parameters were determined in 37 boys with severe haemophilia A and 41 children with other bleeding disorders. The quantity of factor VIII concentrate given to boys with severe haemophilia A (mean U/year) showed a significant inverse correlation with total white cell counts, lymphocyte counts, platelet co...