Introduction Conclusions References

The 2015 Medical History William Bynum Prize attracted a strong field of 12 entries, of which at least half are clearly of publishable quality. The four-person committee deliberated carefully on the essays. A small cluster stood out, necessitating a second round of deliberations. First prize was awarded to the essay by Lori Jones of the University of Ottawa, entitled ‘When Medical Texts Double ...

School attendance records of all primary schools in a guinea worm-endemic village in southwestern Nigeria were examined to determine the cause of missed school days and school drop-outs. At the time of the survey, 1,495 pupils (768 boys and 727 girls were registered in the 4 primary schools in the village, of which 21% of the pupils were infected with guinea worm disease (GWD). Female pupils ha...

A full-length cDNA to guinea pig pulmonary surfactant protein (SP) A was cloned by screening a newborn guinea pig lung cDNA library with a human SP-A cDNA probe. The full-length guinea pig SP-A cDNA consists of 1,839 bp and is highly conserved at both nucleotide and amino acid sequence levels with those from other species. As expected, guinea pig SP-A mRNA is abundantly expressed in adolescent ...

several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of rosa damascena. north american indian tribes use a decoction of the roots obtained from the rosa damascena plant as a cough remedy and to treat eye problem. therefore, in the present study the antitussive effect of this plant in ...

objective: pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. in this study the effects of carvacrol on serum levels of total protein (tp), phospholipase a2 (pla2) and histamine in sensitized guinea pigs was evaluated. materials and methods: sensitized guinea pigs were given drinking water alone (group s), drinking water containing three concentration...

CD1 is a family of cell-surface molecules capable of presenting microbial lipid Ags to specific T cells. Here we describe the CD1 gene family of the guinea pig (Cavia porcellus). Eight distinct cDNA clones corresponding to CD1 transcripts were isolated from a guinea pig thymocyte cDNA library and completely sequenced. The guinea pig CD1 proteins predicted by translation of the cDNAs included fo...

Pancreatic islets from young normal and scorbutic male guinea pigs were examined for their ability to release insulin when stimulated with elevated D-glucose. Islets from normal guinea pigs released insulin in a D-glucose-dependent manner showing a rapid initial secretion phase and three secondary secretion waves during a 120-min period. Islets from scorbutic guinea pigs failed to release insul...

An attempt was made to immunize "strain 2" guinea pigs by superficial skin scarification with small doses of L2C leukemic cell suspensions. Among 203 scarified guinea pigs, 32 developed progressively growing leukemic tumors at the site of skin scarification. In 35 guinea pigs small intradermal tumors that appeared at the site of scarification regressed spontaneously; however, 15 guinea pigs in ...

A Mr 25,000 form of basic fibroblast growth factor (bFGF) has been isolated from guinea pig brain along with the typical Mr 18,000 form. Both forms were purified to homogeneity by a combination of heparin-affinity chromatography and ion-exchange chromatography on an FPLC Mono S column. The Mr 25,000 form, like the Mr 18,000 form, was not eluted from the heparin-affinity column with 0.95 M NaCl,...