1. A new method has been used to measure mean gastric transit time. 2. This method, based on the absorption of 24Na from the proximal small bowel, is simple, non-invasive and can be used at the bedside. 3. The mean transit time was increased by adding guar gum to a test meal. 4. There was a significant correlation between mean gastric emptying time and a subjective measure of satiety.

This study aimed to improve the dissolution rate of aceclofenac and release drug in a controlled manner over period 24 hours. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/guar gum). wet granulation method different Tablets evaluated for vitro profile phosphate buffer with pH 6.8 (without enzymes). The thickness hardness 3.23 ± 0.035 3.28 0.008 mm 3...