background: parathyroid hormone (pth) secreted by parathyroid glands regulates the metabolism of calcium and phosphorus in bone and kidney. thereby, it can stimulate bone formation, and is a promising agent in the treatment of osteoporosis. mature form of pth consists of 84 amino acids; however, the first 34 residues of pth cover the majority of hormonal action. methods: in this study, the fusi...

Fuel Cell–Gas Turbine (FC-GT) hybrid technology portends a significant breakthrough in electrical generation. Hybrid systems reach unprecedented high efficiencies, above 70% LHV in some instances, with little to no pollution, and great scalability. This work investigates two high temperature fuel cell types with potential for hybrid application ranging from distributed generation to central pla...

Genital tubercle (GT) initiation and outgrowth involve coordinated morphogenesis of surface ectoderm, cloacal mesoderm and hindgut endoderm. GT development appears to mirror that of the limb. Although Shh is essential for the development of both appendages, its role in GT development is much less clear than in the limb. Here, by removing Shh at different stages during GT development in mice, we...

Visual signal transduction serves as one of the best understood G protein-coupled receptor signaling systems. Signaling is initiated when a photon strikes rhodopsin (Rho) causing a conformational change leading to productive interaction of this G protein-coupled receptor with the heterotrimeric G protein, transducin (Gt). Here we describe a new method for Gt purification from native bovine rod ...

Rapid sequence induction and intubation (RSII) and awake tracheal intubation are commonly used anesthetic techniques in patients at risk of pulmonary aspiration of gastric or esophageal contents. Some of these patients may have a gastric tube (GT) placed preoperatively. Currently, there are no guidelines regarding which patient should have a GT placed before anesthetic induction. Furthermore, c...

In order to improve the diesel engine performance under plateau (high altitude) conditions, a new Speed Adjustable Compound (SAC) supercharging method is proposed. A simulation model based on a six-cylinder V-type turbocharged intercooler diesel engine is built on the GT-POWER platform, and then simulation-based research is carried out. A genetic algorithm (GA) is used to identify the best oper...

This paper investigates the potential for Leximancer software to actively support the Grounded Theory (GT) analyst in assessing the “completeness” of their study. The case study takes an existing GT study and retrospectively analyzes the data with Leximancer. The Leximancer output showed encouraging similarities to the main themes emerging from the GT analysis; but not sufficiently at the selec...

A model for interaction of class A G protein-coupled receptor with the G protein G(alpha) subunit is proposed using the rhodopsin-transducin (RD/Gt) prototype. The model combines the resolved interactions/distances, essential in the active RD*/Gt system, with the structure of Gt(alpha) C-terminal peptide bound to RD* while stabilizing it. Assuming the interactions involve conserved parts of the...

In this computational study, we have investigated the implications of rhodopsin (Rho) oligomerization in transducin (Gt) recognition. The results of docking simulations between heterotrimeric Gt and monomeric, dimeric and tetrameric inactive Rho corroborate the hypothesis that Rho and Gt can be found coupled already in the dark. Moreover, our extensive computational analysis suggests that the m...

BACKGROUND Abnormal serum gamma-glutamyltransferase (γ-GT) may be an early and sensitive marker for oxidative stress. This study was performed to evaluate the association between serum heavy metals and γ-GT concentration. METHODS This study is a cross-sectional analysis based on data from Korean National Health and Nutrition Examination Survey (V-1, 2, 2010, 2011) regarding serum heavy metal ...