Disruptions in mushroom body (MB) or central complex (CC) brain structures impair Drosophila associative olfactory learning. Perturbations in adenosine 3',5' monophosphate signaling also disrupt learning. To integrate these observations, expression of a constitutively activated stimulatory heterotrimeric guanosine triphosphate-binding protein alpha subunit (Galphas*) was targeted to these brain...

A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression, while alpha-difluoromethylornithine produced a complete growth arrest and a sharp decreas...

(CHEST 1999; 115:267–268) A 50-year-old woman develops a gradual deterioration in oxygenation shortly after single lung transplantation. This patient, with alpha-1-antitrypsin deficiency, undergoes right lung transplantation for emphysema. The surgery performed through a right thoracotomy is uncomplicated and the patient is transferred to the ICU for recovery. Shortly after arrival, the nurses ...

Oculodentodigital dysplasia (ODDD) [MIM 164200] is a rare disorder caused by mutations in the gap junction alpha 1 (GJA1) gene encoding for connexin 43 (Cx43). Typical signs include type III syndactyly, microphtalmia, microdontia, and neurological disturbances. We report a 59-year-old man having clinical symptoms and signs suggestive of ODDD, with some rarely reported features, that is the pres...

We describe the dynamical mass generation in pseudoquantum electrodynamics (PQED) coupled to Gross-Neveu (GN) interaction, ($2+1$) dimensions, at both zero and finite temperatures. start with a gapless model show that, under particular conditions, dynamically generated emerges. In order do so, we use truncated Schwinger-Dyson equation, large-$N$ approximation, imaginary-time formalism. instanta...

The clinical symptoms, gross and histopathological, as well as the ultrastructural appearance of a condition in cross-bred Aberdeen Angus calves resembling the inherited lysosomal storage disease, alpha-mannosidosis, are reported. The neurones and perithelial cells in the brain and the reticuloendothelial cells in the lymph nodes and spleen were extensively vacuolated. The vacuoles were filled ...

Blood lipids have been measured in sera from 750 cadavers. All nine fractions measured show a remarkably consistent pattern of differences between the various gross morbid anatomical forms of ischaemic heart disease. The highest mean values are found when an obvious coronary thrombus is present and those in simple atheromatous occlusion are nearly as high. When there is recognizable necrosis th...

Re-collections of the cyanobacterium Lyngbya sp. have yielded two more members of the lyngbyapeptin and lyngbyabellin families. The gross structures of 15-norlyngbyapeptin A (1) and lyngbyabellin D (3) were deduced through standard 2D NMR techniques, with the absolute configuration of both elucidated through degradation and comparison with commercially available and synthetic standards. Degrada...