chronic granulomatous disease (cgd) is a rare inherited disorder characterized by inability of phagocytes to generate oxygen radicals needed for intracellular killing of phagocytic microorganisms. we report a 2.5-year-old iranian female with multiple liver abscesses. she was admitted in surgical ward because of abdominal pain and fever for one month duration that had no response to conventional...

background langerhans cell histiocytosis (lch) is a rare disease in which monoclonal migration and proliferation of specific dendritic cells is seen. the disease primarily affects the bones and skin, but there is a possibility that involves other organs or appears as a multi-systemic disease. case report in oral examination of a nine-month girl, two deep wounds with a yellow membrane with appro...

PURPOSE To compare the morphologic features of keratic precipitates (KPs) by confocal microscopy in granulomatous versus nongranulomatous noninfectious uveitis. METHODS KP morphology was determined by confocal scan in patients with noninfectious granulomatous and noninfectious nongranulomatous uveitic cases. RESULTS One hundred and twenty-seven eyes of 90 subjects with noninfectious uveitis...

We tested the ability of human neutrophils to kill five Candida species and the yeast Torulopsis glabrata. C. parapsilosis and C. pseudotropicalis were found to be killed readily by normal and myeloperoxidase-deficient neutrophils and were selected to probe the myeloperoxidase-independent fungicidal mechanisms of the neutrophil. These organisms were killed with relatively normal (C. parapsilosi...

Enteric granulomatous inflammation can be caused by a number of conditions including Crohn's disease, sarcoidosis, enteric infections, chronic granulomatous disease and also by drug reactions. Granulomas have also been described in microscopic colitis associated with certain medications and autoimmune diseases. The association of granulomatous ileocolitis with coeliac disease is not common. We ...

Necrobiosis lipoidica is a rare chronic granulomatous disease, often associated with diabetes mellitus. It due to collagen degeneration risk of ulceration. affects 0.3 1.2% diabetic patients, mainly in the leg. Its etiology not yet well understood. The diagnosis usually made clinically but skin biopsy may be necessary case atypical lesions. evolution ulceration and into squamous cell carcinoma ...

Three patients with unexplained synovial inflammation were found to have an ulcerative, granulomatous synovitis on biopsy. Maize starch was identified in giant cells within the granulomata. Starch synovitis has clinical and histological similarities to starch peritonitis, which is thought to be an example of a cell mediated immune response.

A 35 year old man developed paraplegia due to an epidural mass 15 months after completion of a full chemotherapy course for pulmonary and lymph node Mycobacterium bovis infection. His cellular immune function was normal after treatment. It is suggested that the lesion was a granulomatous healing response rather than bacteriological recurrence.