Background: Patients with Diabetes Mellitus are more prone to Urinary tract infection (UTI) than non-diabetic patients. has certain negative effects on the genital system and increases incidence of urinary in diabetic Design: Record based retrospective study. Methods: Records patients type-II diabetes having symptoms UTI were reviewed from August 2021 January 2022. Result: Out 210 patients, rat...

background: neutropenic patients are vulnerable to a wide spectrum of infectious agents. the aim of this study was to determine the current frequency of bacterial infections in patients with nosocomial fever and neutropenia. methods: in a retrospective study, the neutropenic patients’ specimens with nosocomial fever were cultured on blood and macconkey agar plates and evaluated at microbiology ...

To determine the role of Toll-like receptor 4 (TLR4) in the immune response to pneumonia, C3H/HeJ mice (which display a mutant nonfunctional TLR4) and C3H/HeN wild-type mice were intranasally infected with either Streptococcus pneumoniae (a common gram-positive respiratory pathogen) or Klebsiella pneumoniae (a common gram-negative respiratory pathogen). In cases of pneumococcal pneumonia, TLR4 ...

Urinary tract infection is a commonly encountered problem in clinical practice. Diagnosis is usually reached by considering compatible symptoms, microscopy and culture of urine samples. We carried out a retrospective study of records of patients established to have urinary tract infection at King Khalid University Hospital, Riyadh. The results showed the infection predominantly occurring in fem...

Despite improvements in diagnosis and treatment, infections are still a major cause of morbidity and mortality in children with febrile neutropenia. In the majority of febrile episodes, the source of infection cannot be defined. In this study, we aimed to identify the earlier predictors of bacteremia/fungemia and a useful cytokine to identify the source of infection and to discriminate the pati...

Cefatrizine, a new oral semisynthetic cephalosporin, was evaluated in vitro and in the treatment of 18 patients with acute urinary tract infection, pneumonia, and soft tissue infection. In vitro, it was more active than cephalexin for gram-positive and gram-negative bacteria. It was also more active than cephalothin, cefazolin, and cephapirin against most of the gram-negative bacteria but less ...

A difficulty that has emerged in the development and preclinical evaluation of adjuvant therapies for gram-negative sepsis is the lack of easily studied animal models that closely mimic human infection. An objective of this study was to adapt a previously described model of infection in burned mice to rats with a defined bacterial strain of Escherichia coli. Challenge with two colonies of live ...

The global rise of multidrug-resistant gram-negative bacteria represents an increasing threat to patient safety. From the first observation of a carbapenem-resistant gram-negative bacteria a global spread of extended-spectrum beta-lactamases and carbapenemases producing Klebsiella pneumoniae has been observed. Treatment options for multidrug-resistant K. pneumoniae are actually limited to combi...

BACKGROUND Empiric therapy for healthcare-associated infections remains challenging, especially with the continued development of Gram-negative organisms producing extended-spectrum β-lactamases (ESBLs) and the threat of multi-drug-resistant organisms. Current treatment options for resistant Gram-negative infections include carbapenems, tigecycline, piperacillin-tazobactam, cefepime, ceftazidim...