PURPOSE We examined human papillomavirus (HPV) genotype distribution and prevalence from routine Pap smear cases in Korean women using DNA Chip. PATIENTS AND METHODS A total of 2,470 cervical specimens from women attending routine Pap smear cytology screening in local hospitals was subjected to HPV test. HPV detection and genotyping were done using DNA Chip. RESULTS HPV DNA was detected in ...

background: this research was accomplished to evaluate the ihc expression of p16 (ink4a) and ck17 in low grade cervical intraepithelial lesions (lsil), high grade cervical intraepithelial lesions (hsil) and invasive cervical carcinomas and to assess their correlation to hpv (16e6+18e6). methods: the study included (127) formalin-fixed paraffin-embedded cervical biopsies; of which 22 cases were ...

Introduction: Cervical cancer is common and ranked in fourth place both incidence mortality worldwide. It 3rd most female Malaysia with a lifetime risk of 1 116. Infection high-risk oncogenic human papillomavirus (HPV) recognized as one the substantial factors for development cervical cancers. Methods: was cross-sectional study conducted to determine prevalence HPV infection its subtypes among ...

CONTEXT Anal cytology is being used more frequently for anal cancer screening, yet many cytologists are unfamiliar with it. OBJECTIVE To describe the performance of anal cytology in the College of American Pathologists' Interlaboratory Comparison Program in Non-Gynecologic Cytology (CAP NGC) educational slide program during a 6-year time span, from 2006 to 2011, using participant responses (p...

AIMS To test the ability of Ki-67 to detect cytological lesions in a screening setting and its use as a surrogate marker of human papillomavirus (HPV) infection. METHODS A study of liquid based cytology, HPV DNA testing by MY09/MY11 consensus polymerase chain reaction (PCR), type specific PCRs, and Ki-67 immunocytochemistry on a randomly selected series of 147 patients. RESULTS Comparison o...

Cervical and vaginal low-grade squamous intraepithelial lesions (LSIL) are associated with persistent human papillomavirus infections, require an efficacious non-invasive treatment such as photodynamic therapy due to anatomical characteristics. In this study, we evaluated the clinical efficacy safety of a chlorin e6 derivative named STBF-mediated (STBF-PDT) for patients cervical LSIL. A total 1...

OBJECTIVE We sought to test the diagnostic efficacy of a low-cost, liquid-based cervical cytology that could be implemented in low-resource settings. MATERIALS AND METHODS A prospective, split-sample Pap study was performed in 595 women attending a cervical cancer screening clinic in rural El Salvador. Collected cervical samples were used to make a conventional Pap (cell sample directly to gl...

The prevalence of cervical human papillomavirus (HPV) in South African women (n = 1,073) increased from 20.4% (173/848) in women with normal cytology to 41.7% (48/115) in women with atypical squamous cells of undetermined significance, 70.2% (40/57) in women with low-grade squamous intraepithelial lesions, and 83% (44/53) in women with high-grade squamous intraepithelial lesions (HSILs). HPV ty...

A fundamental controversy in using biomarkers to diagnose cervical cancer precursors [ie, squamous intraepithelial lesions (SIL)] is their lack of specificity for high-grade SIL [HSIL; cervical intraepithelial neoplasia grade 2/3 (CIN2/3)]. Stathmin-1 (STMN), a microtubule-destabilizing protein important in mitosis, is overexpressed in a variety of malignancies including those from the Mülleria...

Objective: The study aimed to evaluate liquid based cytology as a tool for cervical cancer screening in Georgia. Materials and Methods: 1293 cervical cytology samples have been analyzed in Georgia. The samples had been collected and processed by the usage of materials and equipment provided by Hologic. Prepared smears were post-fixed in 96% ethanol and stained accordingly with Papanicolau proto...