Abstract Background Prokineticin receptor 2 ( PROKR2 ) loss of function mutations have been described as cause hypogonadotropic hypogonadism. In 2017, a first case central precocious puberty (CPP) caused by heterozygous gain mutation was in 3.5 years-old girl. No other cases reported yet. This study performs molecular screening girls with early onset CPP (breast budding before 6 years age) to i...