Abstract Osteoarthritis (OA) of the knee (gonarthrosis) is a degenerative rheumatic disease, which most common disease. Numerous factors, such as mechanical, enzymatic, and biological, are responsible for development this complex, multifactorial The connection between inflammation OA being investigated more more. Cytokines thought to be one main causes disturbances in normal cartilage metabolis...

Osteoarthritis (OA) is a multifactorial disease that can be caused by genetic factors, obesity, joint microtrauma, and excessive physical exercises. The key features of OA include gradual loss articular cartilage, bone tissue remodeling, development osteophytes, subchondral sclerosis. pathogenesis based on the glycosaminoglycans, collagen disorganization, inflammation mediated cytokine cascade....

BACKGROUND To perform total knee arthroplasty, some surgeons prefer to use a fixed valgus angle, for example 5° or 6°, for the distal femoral cut with every patient. This angle may be appropriate for some patients, but may not be for all. OBJECTIVE To determine the proper angle of the distal femoral cut during total knee arthroplasty (TKA) in Thai patients with osteoarthritis of the knee. M...

The viability of unicondylar knee arthroplasty (UKA) as a stand-alone or temporising option for the management of gonarthrosis is a topic of considerable contention. Despite recent advances in prosthesis design and surgical technique, as well as mounting evidence of long-term survivorship, UKA remains infrequently used, accounting for just 8-15% of all knee arthroplasties. Instead this group is...

BACKGROUND Thanks to defense mechanisms, organisms have had to adapt themselves to an adverse natural setting that causes acute and chronic stress. This adaptive response that tries to protect the cells against lethal insults uses its own defense systems. MATERIAL AND METHODS Prospective, observational, descriptive pilot study with analytic components to determine the baseline preoperative TN...

The aim of the study was to evaluate the mid-term clinical results and survivorship of a rotating-hinge knee prosthesis (LINK® Endo-Model) in difficult primary and complex revision situations. Results after primary implantation were compared with those of revision procedures. Forty-nine prostheses in 45 patients were reviewed clinically during follow up. Twenty-one of these were implanted in pr...