Gemcitabine (GMT) is a nucleoside analog used in the treatment of variety solid tumors. GMT was chemically modified with hydrolysable linker, and subsequently incorporated into poly(anhydride-ester) backbone via melt-polymerization, active antimetabolite GMT, thus, becoming repeat unit that makes up this new material, biodegradable polymer. Characterization structure polymeric (polyGMT) reveale...

This document describes an experiment with the purpose of developing a proof-of-concept for a prototype for a workflow component for GMT, the Generative Model Transformer Open Source effort. It discusses the challenges we met in trying to adhere to standards and the problems of using existing “wizards”. Despite this, generative development proved to be effective.

Training for both sporting and military performance is common practice within army trainee populations, although it currently unknown what effect this combination of training methods may have on the physical attributes required overall preparedness. This study examined effects sport-specific general fitness in a professional population. Four hundred twenty-three Greek male cadets completed 12-w...

This study was done to investigate the antibody response to a Vero cell antirabies vaccine, the persistence of antibody for 5 years, and the effect of a booster dose after this interval. From August 2005 to February 2011, a total of 195 patients were enrolled into our study due to an animal bite. The Essen intramuscular (i.m.) regimen, which is recommended by the WHO for modern vaccines used in...

BACKGROUND Antibodies to measles, mumps, and rubella decline 3% per year on average, and have a high degree of individual variation. Yet, individual variations and differences across antigens are not well understood. To better understand potential implications on individual and population susceptibility, we reanalyzed longitudinal data to identify patterns of seropositivity and persistence. M...

OBJECTIVE To assess the effect of rituximab on the efficacy and safety of influenza virus vaccine in patients with rheumatoid arthritis (RA). METHODS The study group comprised patients with RA treated with conventional disease-modifying drugs with or without rituximab. Split-virion inactivated vaccine containing 15 microg haemagglutinin/dose of B/Shanghai/361/02 (SHAN), A/New Caledonian/20/99...

Article 2 of the United Nations Framework Convention on Climate Change [United Nations (1992) http://unfccc.int/resource/docs/convkp/conveng.pdf. Accessed February 9, 2009] commits signatory nations to stabilizing greenhouse gas concentrations in the atmosphere at a level that "would prevent dangerous anthropogenic interference (DAI) with the climate system." In an effort to provide some insigh...

An unusual, highly diverged derivative of the Sabin type 2 oral poliovaccine (OPV) strain was recovered from environmental samples during routine screening for wild polioviruses. Virus was cultivated in L20B cells and then passaged on BGM cells at 40 degrees C (RCT [reproductive capacity at supraoptimal temperature]-positive marker) to select against most OPV strains. All but 1 of 25 RCT-positi...

BACKGROUND While the immunogenicity and effectiveness of seasonal influenza vaccines among subjects with severe motor and intellectual disability (SMID) are known to be diminished, the efficacy of the A/H1N1pdm vaccine has not been evaluated. METHODS We prospectively evaluated 103 subjects with SMID (mean age, 41.7 years) who received trivalent inactivated influenza vaccine during the 2010/11...

BACKGROUND Clusterin is a glycoprotein which participates in a number of pathophysiological processes in the organism. Information about clusterin use in the diagnosis of nephropathy and the differential diagnosis of proteinuria has been published recently. AIM Search for correlations between urinary clusterin concentration and other renal function markers. Evaluation of urinary clusterin mea...