نتایج جستجو برای: glycine rich loop

تعداد نتایج: 311334  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Remigijus Lape Andrew J R Plested Mirko Moroni David Colquhoun Lucia G Sivilotti

Loss-of-function mutations in human glycine receptors cause hyperekplexia, a rare inherited disease associated with an exaggerated startle response. We have studied a human disease mutation in the M2-M3 loop of the glycine receptor α1 subunit (K276E) using direct fitting of mechanisms to single-channel recordings with the program HJCFIT. Whole-cell recordings from HEK293 cells showed the mutati...

Journal: :American Journal of Physiology-Endocrinology and Metabolism 2018

2017
Dieter Janzen Natascha Schaefer Carolyn Delto Hermann Schindelin Carmen Villmann

Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an involvement of the extracellular β8-β9 loop in the transition from ligand-bound receptors to the ...

Journal: :The Journal of biological chemistry 2009
Jane E Carland Michelle A Cooper Silas Sugiharto Hyo-Jin Jeong Trevor M Lewis Peter H Barry John A Peters Jeremy J Lambert Andrew J Moorhouse

The Cys loop receptor channels mediate fast synaptic transmission in the nervous system. The M2-demarcated transmembrane pore is an important determinant of their ion permeation properties. Portals within the intracellular domain are also part of the permeation pathway in cationic Cys loop receptors, with charged residues in a helical MA stretch partially lining these openings profoundly affect...

Journal: :The Journal of biological chemistry 1997
X Shen A M Belcher P K Hansma G D Stucky D E Morse

A specialized extracellular matrix of proteins and polysaccharides controls the morphology and packing of calcium carbonate crystals and becomes occluded within the mineralized composite during formation of the molluscan shell and pearl. We have cloned and characterized the cDNA coding for Lustrin A, a newly described matrix protein from the nacreous layer of the shell and pearl produced by the...

Journal: :Physiological and biochemical zoology : PBZ 2011
Carol Bucking Chris N Glover Chris M Wood

Hagfish feed by immersing themselves in the body cavities of decaying animals. This ensures a rich nutrient source for absorption via the gills, skin, and gut, but it may also subject hagfish to reduced levels of dissolved oxygen and elevated levels of the products of biological degradation. This study investigated the impacts of hypoxia and ammonia on the assimilation and metabolism of selecte...

Journal: :Journal of cell science 2004
Ulrich Ryser Martine Schorderet Romain Guyot Beat Keller

The water pipes of elongating plant organs are the result of programmed cell death and are formed by the walls of dead and empty protoxylem elements. These protoxylem elements are passively elongated many times by the surrounding tissue before they are replaced and collapse. Well-known adaptations for this unique task include the characteristic secondary wall thickenings, forming rings and heli...

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