Celiac disease is a disease where both children and adults are affected. It symptoms were previously described in Galen times. Today we recognize its starter, pathological mechanism, and also its atypical behaviour. There is only one causal therapeutic model in terms of compliance with the principles of lifelong strict gluten-free diet. It is an under-diagnosed disease. Further steps should be ...

Celiac disease is a lifelong disorder for which there is currently only one known, effective treatment: a gluten-free diet. New treatment approaches have recently emerged; several drugs are in Phase 2 trials and results appear promising; however, discussion around regulatory endpoints is in its infancy. We will briefly discuss the drugs that are under development and then shift our attention to...

Following the original description of lymphoma complicating coeliac disease [1], it has become clear that patients with coeliac disease have a 50to a 100-fold increased risk of developing malignant lymphoma compared with the general population [2,3]. The exact risk is unknown as the precise prevalence and incidence of coeliac disease in the population is also unknown. Lymphoma may present in tw...

BACKGROUND Celiac disease (CD) has a negative impact on the health-related quality of life (HRQL) of affected patients. Although HRQL and its determinants have been examined in Spanish CD patients specifically recruited in hospital settings, these aspects of CD have not been assessed among the general Spanish population. METHODS An observational, transversal study of a non-randomized, represe...

AIMS Diagnostics and follow-up of celiac disease have gradually shifted from tertiary centers to secondary and primary health care. In order to establish whether this has affected the success of treatment, and to identify predictors for dietary non-adherence, we carried out a study in a nationwide cohort of treated celiac patients. PATIENTS AND METHODS 843 biopsy-proven patients, 94 children ...

The suggestion has been made that malignancy anywhere in the body may be accompanied by intestinal mucosal changes similar to those found in adult coeliac disease (Creamer, 1964). The following case report indicates that characteristic jejunal mucosal changes, once reverted to normal by a gluten-free diet, do not reappear if a malignancy develops, providing that the gluten-free diet is maintained.

The rise in gluten consumption over time has led to the increasing recognition of coeliac disease (CD) with associated complications. However, only recently has there been an appreciation that the spectrum of gluten-related disorders is greater than just CD, which may explain the growing global popularity in gluten-free products. Current literature suggests that a newly recognised clinical enti...