The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The methanol extract of Berberis tinctoria Lesch (Berberidaceae) leaves was investigated for its hepatoprotective and antioxidant effects on paracetamol (750 mg/kg) induced acute liver damage in Wistar albino rats. Hepa...

Homeopathy is considered as one modality for cancer therapy. However, there are only very few clinical reports on the activity of the drugs, as well as in experimental animals. Presently we have evaluated the inhibitory effects of potentized homeopathic preparations against N'-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in rats as well as 3-methylcholanthrene-induced sarcomas in...

Berberis aristata DC (Berberidaceae) is used in Indian traditional medicine. The hepatoprotective activity of Berberis aristata stem bark suspension was studied using CCl4 overdose induced liver damage in rats. The activity was assessed by monitoring various liver functions testing enzymes viz, Serum Glutamate Pyruvate transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum...

The study was conducted to screen for the phytochemicals constituents of bark of Saraca asoca (Roxb.), one of the folk medicinal plants found in West Bengal, Bangladesh and Sri Lanka. The acute and subacute toxicity of methanolic extract of S. asoca bark on mice was studied. Phytochemical analysis of S. asoca (bark) methanolic extract revealed the presence of high percentage of flavonoids and r...

A new flavonoid C-glycoside, kaempferol 8-C-beta-galactoside, along with twelve known glycosidic flavonoids was isolated from the aqueous methanolic extract of Solanum elaeagnifolium Cav. (Solanaceae), by conventional chromatographic methods; their structure elucidation was achieved using UV, ESI-MS, and NMR spectral analyses. Groups of six mice were administered S. elaeagnifolium extracts at 2...

Von Willebrand factor (VWF) is the carrier protein of the anti-haemophilic Factor VIII (FVIII) in plasma. It has been reported that the infusion of FVIII concentrate in haemophilia A patients results in lowered VWF plasma levels. However, the impact of F8-deficiency on VWF plasma levels in F8-/y mice is unresolved. In order to avoid confounding variables, we back-crossed F8-deficient mice onto ...

We implemented a nationwide population-based study in Taiwan to compare the physical and biochemical parameters, diet and exercise lifestyles, and prevalences of diabetes, hyperlipidemia, and hypertension between males and females, and to clarify the determinants of diabetes, hyperlipidemia, and hypertension in Taiwan. In this cross-sectional study, 7,578 subjects were selected from the general...

Copyright  2014 irjpbs The aim of this work is to study the hepatoprotective effect of polyherbal formulations contains some Indian medicinal plant. The three different herbal formulations obtained from different medicinal plant extracts were evaluated for hepatoprotective in rats by induced liver damage by paracetamol. Paracetamol (3g/kg, p.o) was administered a single dose to induce hepatoto...

This study was aimed at the synthesis of few xanthone derivatives containing 1,4-dioxane ring system. The reaction of 3,4-dihydroxy xanthone derivatives (3a-c) with ethylene dibromide and epichlorohydrin under approriate reaction conditions afforded xanthone derivatives containing 1,4-dioxane ring system (4a-e). The structures of the synthesized compounds were confirmed on the basis of their ch...

Background: Little information is available on the trend in cardiovascular risk factors and hepatic enzymes in Iranian seafarers. The present study aimed to assess the pattern of obesity, hypertension, diabetes, elevated serum glutamic oxaloacetate transaminase (SGOT), and serum glutamate pyruvate transaminase (SGPT) in Iranian seafarers during 2010 to 2014. Methods: Data on cardiovascular r...