The sensitivity and specificity of the inhibition of β-glucosidase (Amygdalae dulces) by (+ )-catechin, an oxidized (+)-catechin solution, three dimeric procyanidins, and five (+)-catechin dimers obtained by enzymatic oxidation were evaluated by using a chromatographic method. All the polyphenols tested presented a significant inhibitory effect. Non-competitive inhibition was observed for the o...

Starch digestion involves the breakdown by α-amylase to small linear and branched malto-oligosaccharides, which are in turn hydrolyzed to glucose by the mucosal α-glucosidases, maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI). MGAM and SI are anchored to the small intestinal brush-border epithelial cells, and each contains a catalytic N- and C-terminal subunit. All four subunits have α-1...

α-Glucosidase inhibition is considered as an effective strategy for the treatment of diabetes mellitus. Currently, three α-glucosidase inhibitors are being used drugs; Acarbose, Voglibose and Miglitol. The side effects these drugs forcing researchers to search new molecules. In this research work, novel 1,2,3-benzotriazin-4(3H)-one sulfonamides were synthesized investigated their activity. 2,4,...

BACKGROUND Diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. In the African region this rate is the highest, with 20 million diagnosed diabetics. Despite a noticeable progress in the treatment of diabetes mellitus by synthetic drugs, the search for new natural anti-diabetic agents is going on. Nauclea diderrichii (De Wild.) Merr. (ND) and Sarco...

Introduction:Byrsonima garcibarrigae is an endemic tree of Amazonas state, Brazil, with pharmacological and chemical knowledge poorly understood. Aim: To investigate the antidiabetic potential B. stem bark. Methods: The bark was sequentially extracted by maceration hexane (EHBG), ethyl acetate (EABG), methanol (EMBG). antioxidant capacity, α-glucosidase inhibitory potentials anti-glycation capa...

The most prevalent subtype of diabetes is Type 2 Diabetes Mellitus which results from an abnormal postprandial increase in blood glucose. Inhibition the carbohydrate-hydrolysing enzymes (alpha-glucosidase and alpha-amylase) human digestive organs can control glucose levels, making it important strategy management Mellitus. A majority oral synthetic drugs have been developed to treat are expensi...