the snail caucasotachea lencoranea mousson is a pest of citrus in the north provinces of iran. in order to adopt a better control of the pest and develop optimal management strategies, an understanding of the digestive enzymes’ function is inevitable. snails were collected from some citrus orchards in the northern provinces of the country and digestive carbohydrases including ?-glucosidase, ?-g...

A Thai polyherbal antipyretic remedy, TPDM6315, consists of herbal constituents that possess anti-diabetic properties. It contains 15 plants, which the roots 3 crude drugs, Solanum indicum (R-Si), trilobatum (R-St), and Gymnopetalum integrifolium (R-Gi), are insufficiently supplied in market, while their stems or aerial parts (S-Si, S-St, S-Gi, respectively), available. This study aimed to dete...

This study was designed to investigate the structure of synthesized hesperidin glycosides (HGs) and evaluate their antibacterial α-glucosidase inhibitory activities. The preliminary HGs confirmed by glucoamylase treatment analyzed on thin layer chromatography (TLC). LC-MS/MS profiles showed important fragments at m/z ratios 345.21 (added glucose rutinose in HG1) 687.28 maltose HG2), confirming ...

Chemical investigation of the endophytic fungus Aspergillus sp. 16-5B cultured on Czapek's medium led to the isolation of four new metabolites, aspergifuranone (1), isocoumarin derivatives (±) 2 and (±) 3, and (R)-3-demethylpurpurester A (4), together with the known purpurester B (5) and pestaphthalides A (6). Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The...

The Lauraceae genus Litsea includes many tree species with pharmacological capabilities, including anti-diabetic benefits. Five plant were tested for their activity on α-amylase and α-glucosidase. This study evaluated phytochemical composition, phenolic flavonoid levels, α-glucosidase inhibitor of elliptica, ferruginea, firma, garciae, sp. Phytochemical screening was performed using specific re...

The anti-diabetic potential of whole unripe jackfruit (peel with pulp, flake, and seed) was investigated using inhibitory assays for α-glucosidase, α-amylase, aldose reductase, glycation at multiple stages. Using activity-guided repeated fractionation on a silica gel column chromatography, dietary flavonoid rutin potent antihyperglycemic activity extracted from the methanol extract flour (MJ). ...

In this study, the antidiabetic potential of aqueous extract Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination kidney were evaluated. The administration carvacrol to group rats caused significant decrease glucose, parameters serum signif...

The alpha-glucosidase inhibitor bromoconduritol (6-bromo-3,4,5-trihydroxycyclohex-1-ene) inhibits trimming of the innermost glucose residue from the Glc3Man9GlcNAc2 precursor of high-mannose and complex oligosaccharides. This inhibition occurs both in intact cells and with a microsomal enzyme preparation. The formation of lipid-linked oligosaccharides was increased in glucosidase-inhibited cell...

Competitive glycosidase inhibitors are generally sugar mimics that are costly and tedious to obtain because they require challenging and elongated chemical synthesis, which must be stereo- and regiocontrolled. Here, we show that readily accessible achiral (E)-1-phenyl-3-(4-strylphenyl)ureas are potent competitive α-glucosidase inhibitors. A systematic synthesis study shows that the 1-phenyl moi...

Two new sulfur-containing benzofuran derivatives, eurothiocin A and B (1 and 2), along with five known compounds, zinniol (3), butyrolactone I (4), aspernolide D (5), vermistatin (6), and methoxyvermistatin (7), were isolated from the cultures of Eurotium rubrum SH-823, a fungus obtained from a Sarcophyton sp. soft coral collected from the South China Sea. The new compounds (1 and 2) share a me...