AimsThis systematic review and meta-analysis aims to evaluate the safety efficacy of newer glucose lowering treatments on glycemic control, weight, blood pressure hypoglycemia in patients with T2DM during Ramadan.MethodsA literature search was done PubMed, Embase, Cochrane Library. Quality assessment using ROBINS-I tools for risk bias analyses were performed RevMan version 5.3.ResultsA total 20...

Dapagliflozin which is also known as Farxiga in the US and Forxiga EU a drug was developed by Bristol-Myers Squibb partnership with Astra Zeneca. It available Oxra it marking Sun Pharmaceutical Industries Ltd. contains active substance second member of selective sodium glucose co-transporter-2 (SGLT-2) inhibitor first group among oral anti-diabetic agents are independent insulin secretion. The ...

The effects of a similar exercise training stimulus on maximal insulin-stimulated (MIS) plasma membrane glucose transporter number and glucose transport were determined in lean and obese SHHF/Mcc-facp rats. Six-week-old lean and obese male rats were randomly divided into four groups: lean sedentary (LSed), obese sedentary (OSed), lean exercise (LEx), and obese exercise (OEx). An 8- to 12-wk tre...

Increased renal clearance of thiamine (vitamin B(1)) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy. We studied the mechanism of impaired renal re-uptake of thiamine in diabetes. Expression of thiamine transporter proteins THTR-1 and THTR-2 in normal human kidney sections ...

Objective(s): The aim of this study was to explore the molecular mechanism of mirtazapine with respect to energy metabolism in Streptozotocin-induced diabetic liver of rats by immunohistochemistry and Western blot. Materials and Methods: Twenty-one male Sprague-Dawley rats were assigned into 3 groups including control, type 1 diabetes me...

Recently, we reported the cloning of a putative glucose transporter (OnmyGLUT1) from rainbow trout embryos. In this paper, we describe the functional characteristics of OnmyGLUT1 and its expression during embryonic development of rainbow trout. Transport of D-glucose was analysed in Xenopus laevis oocytes following microinjection of mRNA transcribed in vitro. These experiments confirmed that On...