By RAMON M. SUAREZ, ROBERTO Buso, LEO M. MEYER AND S. T. OLAVARRIETA T HE FIRST STUDY on sicklemia in Puerto Rico was that of Pons and Oms ( 1934) #{149}l They reported an incidence of sickling in 5.6 per cent of the StIl)ject5 studied. sIore recently ( 1957 ) Torregrosa, Rivera Trujillo and Ruiz Soler2 reported an incidence cf sicklemia of 4.2 per cent in a series of 618 Puerto Ricans. In a gr...

By RAMON M. SUAREZ, ROBERTO Buso, LEO M. MEYER AND S. T. OLAVARRIETA T HE FIRST STUDY on sicklemia in Puerto Rico was that of Pons and Oms ( 1934) #{149}l They reported an incidence of sickling in 5.6 per cent of the StIl)ject5 studied. sIore recently ( 1957 ) Torregrosa, Rivera Trujillo and Ruiz Soler2 reported an incidence cf sicklemia of 4.2 per cent in a series of 618 Puerto Ricans. In a gr...

By RAMON M. SUAREZ, ROBERTO Buso, LEO M. MEYER AND S. T. OLAVARRIETA T HE FIRST STUDY on sicklemia in Puerto Rico was that of Pons and Oms ( 1934) #{149}l They reported an incidence of sickling in 5.6 per cent of the StIl)ject5 studied. sIore recently ( 1957 ) Torregrosa, Rivera Trujillo and Ruiz Soler2 reported an incidence cf sicklemia of 4.2 per cent in a series of 618 Puerto Ricans. In a gr...

AIMS/INTRODUCTION The influence of overweight/obesity on the clinical efficacy and safety of sodium-glucose co-transporter 2 inhibitors is unclear. We carried out a pooled analysis to examine the impact of body mass index on the efficacy and safety of ipragliflozin. MATERIALS AND METHODS Patient-level data were pooled for five Japanese double-blind trials (NCT00621868, NCT01057628, NCT0113543...

We looked for abnormal hemoglobins in blood samples sent for diagnosis of anemia. Identification of the hemoglobins was made using electrophoretic, chromatographic and molecular procedures. The 2020 blood samples were of patients from various regions of Brazil and from some other Latin American countries. Among the abnormal hemoglobins that we found, 3.5% are known to be rare, while 51% had an ...

AIMS/INTRODUCTION The aim of the present study was to evaluate the long-term efficacy and safety of adding repaglinide in patients with type 2 diabetes mellitus whose blood glucose levels were not sufficiently controlled by treatment with a dipeptidyl peptidase-4 inhibitor, sitagliptin, in addition to diet and exercise therapies. MATERIALS AND METHODS This was a multicenter, uncontrolled, dos...

The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria. In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural variant hemoglobin S and alpha(+)-thalassemia, a condition characterized by reduced production of the normal alpha-globin component of hemoglobin. Individually, each is protecti...

Hemoglobin released into the circulation during hemolysis or therapy with chemically modified hemoglobins, exert oxidative and NO-scavenging toxic effects. Pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) is one of the second-generation hemoglobin-based oxygen carriers (HBOCs). We wanted to investigate the metabolism of PHP with a special focus on its consequences for interpreting hemol...

OBJECTIVE To determine whether the inferior turbinate, which contains swelling bodies, and the nasal septum (Kiesselbach area), characterized by a dense arterial mesh, exhibit different swelling mechanisms in allergic nasal reactions. DESIGN Two optical rhinometers were used to examine 11 patients in the clinic. Optical rhinometry is based on the transillumination of the nasal septum and infe...

Exercise interventions are recommended in most guidelines for the treatment of type 2 diabetes. Although most guidelines suggest a combination of both aerobic and resistance training, the exact benefits of these interventions remain unclear. Although either modality alone or in combination seems to have an identical impact on glycated hemoglobin levels, resistance training and aerobic training ...