BACKGROUND The recently published histopathologic classification of antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis might greatly aid in the prognostication of patients at the time of diagnosis. This study aims to re-evaluate the new classification for its prognostic capacity in an independent Chinese series. METHODS One hundred and twenty-one consecutive patients wit...

To date, no specific treatment is established in mesangial proliferative glomerulonephritis in humans. Specific stimulation of soluble guanylyl cyclase (sGC), an enzyme catalyzing the synthesis of cGMP from GTP, can be achieved by the novel pyrazolopyridine derivative BAY 41-2272. The effect of sGC stimulation via BAY 41-2272 on mesangial proliferation was assessed in vivo using a mesangial pro...

A case is presented of immune complex proliferative glomerulonephritis associated with peripheral eosinophilia, renal deposits of IgE, and eosinophils in glomeruli and interstitial tissue. Two sequential renal specimens are described. This study also reviews prior reports of IgE in glomerulonephritis and discusses possible explanations for the presence of IgE.

Four patients with idiopathic membranous glomerulonephritis, heavy proteinuria and progressive renal failure received azathioprine and prednisolone. Renal function improved in all four and proteinuria declined sharply in three. We suggest that treatment with azathioprine and prednisolone may be of benefit in this form of idiopathic membranous glomerulonephritis.

Nocardial brain abscesses remain a clinical challenge. We successfully treated a patient with nocardial brain abscess, mycetoma, pneumonia, and glomerulonephritis. Nocardial soft tissue involvement, mycetoma, is well known. However, the fact that actinomycetoma can metastasize may not be as well appreciated. The association between nocardiosis and glomerulonephritis should be better clarified.

Key words: cyclosporin A; membranous glomerulo-normal. An echo-Doppler eliminated renal-vein thrombosis. Percutaneous renal biopsy showed a minimal-nephritis; minimal-change glomerulonephritis; nephro-tic syndrome; pure red cell aplasia;thymoma change glomerulonephritis: at light-microscopy all glomeruli appeared normal, there were a few epithelial alterations of the proximal tubules and modera...

Pauci -immune necrotising glomerulonephritis with extracapillary proliferation is a common renal histological manifestation of systemic vasculitis. Although its aetiopathogenesis is not well known, it is possible that environmental factors may have a bearing on genetically predisposed subjects, since there are many familial cases of systemic vasculitis. The frequent association between systemic...

BACKGROUND Nitric oxide (NO) plays important roles in a variety of pathophysiological processes. It has been reported that inducible NO synthase (iNOS) is upregulated in the glomeruli of patients with glomerulonephritis, although there has been no direct evidence that NO generated by iNOS contributes to the progression of glomerulonephritis. ONO-1714, a novel cyclic amidine analog, is a selecti...

BACKGROUND Glomerulonephritis (GN) is a relatively rare disease with numerous subtypes. Most regional nephrology centres see only a limited number of patients with each type of GN every year. The objective of this study was to find out the pattern of glomerulopathies in paediatric population, undergoing renal biopsy in Peshawar. METHODS This was a prospective study carried out at the Departme...

BACKGROUND AND OBJECTIVES There have been few large population-based studies of the association between rheumatoid arthritis (RA) and chronic kidney disease (CKD) and glomerulonephritis. This nationwide cohort study investigated the risks of developing CKD and glomerulonephritis in patients with RA, and the associated risks for cardiovascular complications. METHODS From the Taiwan National He...