at 30 minutes after intravenous administration of the glomerular renal agent tc-99m-dtpa, both right and left lateral views were obtained. we analyzed the ratio of optical densities (behind the ureter/in front of the ureter). in patients without gross renal failure or retroperitoneal disease, the ratio was always less than 1 (range 0.38 to 0.95, mean 0.68). this represents greater perfusion of ...

Glomerular development was studied in the newborn rat kidney by electron microscopy and cytochemistry. Glomerular structure at different developmental stages was related to the permeability properties of its components and to the differentiation of anionic sites in the glomerular basement membrane (GBM) and on endothelial and epithelia cell surfaces. Cationic probes (cationized ferritin, ruthen...

The demonstration by Polonovski, Jayle, Boussier and Badin (1, 2) that certain plasma proteins have the property of binding extracorpuscular hemoglobin has led to recent re-evaluation of the mechanisms of renal transport of hemoglobin in the dog (3) and in man (4). Lathem (4) showed that circulating extracorpuscular hemoglobin is bound quantitatively to the a2-globulin, haptoglobin. By utilizin...

Diabetic kidney disease (DKD) has become a global health concern, with about 40% of people living type 1 and 2 diabetes mellitus developing DKD. Upregulation vascular endothelial growth factor (VEGF) in the is significant pathology DKD associated increased glomerular permeability. To date, however, current anti-VEGF therapies have demonstrated limited success treating Recent studies shown that ...