OBJECTIVES The DPP-4 inhibitors are incretin-related drugs that improve hyperglycemia in a glucose-dependent manner and have been reported to exert favorable effects on atherosclerosis. However, it has not been fully elucidated whether DPP-4 inhibitors are able to improve endothelial function in patients with type 2 diabetes. Therefore, we investigated the efficacy of sitagliptin, a DPP-4 inhib...

AIM To compare the effects of combining liraglutide (0.6, 1.2 or 1.8 mg/day) or rosiglitazone 4 mg/day (all n >or= 228) or placebo (n = 114) with glimepiride (2-4 mg/day) on glycaemic control, body weight and safety in Type 2 diabetes. METHODS In total, 1041 adults (mean +/- sd), age 56 +/- 10 years, weight 82 +/- 17 kg and glycated haemoglobin (HbA(1c)) 8.4 +/- 1.0% at 116 sites in 21 countr...

Floating matrix tablets of Glimepiride were developed to enhance its bioavailability by prolonging the gastric residence time in which Glimepiride was chosen as a model drug because of its has incomplete absorption due to its low gastric residence time. Floating matrix tablets were prepared using melt granulation technique. Bees wax was used as a hydrophobic meltable material. Hydroxypropylmeth...

Trigonella foenum graecum (Fenugreek) is a popular herb widely used for culinary and pharmaceutical purposes. The seeds of the plant have been intensively studied, as they exhibit plenty pharmacological properties. objective current research was to investigate hypoglycemic effect fenugreek in vitro vivo. Aqueous (Aq. ex) ethyl acetate (ETAC. extracts were prepared from grinded seeds. α-amylase ...

Background: Diabetes mellitus is a chronic disease and responsible for the significant morbidity mortality. It critical to conduct drug use research of anti-diabetic medications in order encourage rational diabetes.
 Objective: The purpose this study was analyze pattern antidiabetic drugs, as well prevalence diabetes related risk factors throughout treatment period our sample group.
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Diabetes mellitus is a disease characterized by hyperglycemia. Antidiabetic research using natural ingredients has been carried out lot, one of which utilizing red betel leaves and granite leaves. Combining two plants must be done to increase the antihyperglycemic effect reduce toxic effects. This study aimed obtain most effective dose variations in combinations that are safer have better resul...

Penelitian ini dilakukan di RSUD Rupit, Kabupaten Musi Rawas Utara pada bulan Desember 2022 sampai Januari 2023 merupakan penelitian observasional menggunakan studi deskriptif dengan pengumpulan data secara retrospektif terhadap rekam medis pasien BPJS rawat jalan diagnosa DM tipe 2Tujuan untuk mengetahui pengaruh kombinasi metformin-insulin glargine dan metformin-glimepiride kadar gula darah s...

A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia-c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.

Sulfonylureas (SUs) are widely used insulin secretagogues, but they have adverse effects including hypoglycemia and secondary failure. Fasiglifam/TAK-875, a selective GPR40 agonist, enhances glucose-stimulated insulin secretion and improves hyperglycemia. In the present study, we compared the in vivo glucose-lowering effects of fasiglifam with SUs. The risk of secondary failure of fasiglifam an...