INTRODUCTION The giant left atrium (GLA) is a complication of severe mitral valve disease and causes morbidity by compressing adjacent intra-thoracic structures. CLINICAL PICTURE We report 2 cases of unusual pulmonary complications of the GLA. Case 1 developed recurrent collapse of the left lung due to left main bronchus compression. Case 2 was diagnosed with right middle lobe compression and...

Generalised lymphatic anomaly (GLA), also known as lymphangiomatosis, is a rare disease caused by congenital abnormalities of lymphatic development. It usually presents in childhood but can also be diagnosed in adults. GLA encompasses a wide spectrum of clinical manifestations ranging from single-organ involvement to generalised disease. Given the rarity of the disease, most of the information ...

In the London context, population and economic growth have created acute pressures on housing. London’s population is projected to increase by around 1.14 million to 8.71 million by 2026 (GLA, 2006a) whilst employment is projected to increase by 912,000 jobs between 2006 and 2026 (GLA Economics, 2007). The Further Alterations to the London Plan has set targets of building over 30,000 new homes ...

Generalized Lloyd Algorithm(GLA) is important in vector quantizer design. It runs fast, but it is sensitive to initial conditions and it may find a local optimum. We propose an improved approach based on GLA, named vector quantized codebook reorganization algorithm (VQCRA). VQCRA finds better codebooks in less time, and is insensitive to initial conditions as compared with GLA.. The experiments...

The NPH era started in 1946 and ended nearly 60 years later with the introduction to the market of the long-acting analogs, glargine in 2000 (1) and detemir in 2004 (2). More recently, a secondgeneration acylated long-acting insulin analog, degludec (3), has becomeavailable in some countries outside the U.S. In this issue of the journal, Becker et al. (4) report on pharmacokinetics (PK) and pha...

Anderson-Fabry disease (E C 3.2.1.22, MIM 301500) is an X linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (GLA). 2 The onset of the disease and the severity of clinical manifestations depend principally on residual GLA enzymatic activity. Fabry disease can be classified into two clinical phenotypes: the classical form and the cardiac variant. 3 The class...

Anderson-Fabry disease (E C 3.2.1.22, MIM 301500) is an X linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (GLA). 2 The onset of the disease and the severity of clinical manifestations depend principally on residual GLA enzymatic activity. Fabry disease can be classified into two clinical phenotypes: the classical form and the cardiac variant. 3 The class...

Malignant gliomas are among the most devastating of cancers and are a major cause of mortality in a young population with a median survival time of 9 months following cytoreductive surgery, radiotherapy and chemotherapy. Recent studies showed that polyunsaturated fatty acids especially gamma-linolenic acid (GLA) have selective tumoricidal action especially against malignant glioma cells both in...

BACKGROUND To deliver insulin glargine 300 U/mL (Gla-300), the widely used SoloSTAR(®) pen has been modified to allow for accurate and precise delivery of required insulin units in one-third of the volume compared with insulin glargine 100 U/mL, while improving usability. Here we compare the accuracy and injection force of 3 disposable insulin pens: Gla-300 SoloSTAR(®), FlexPen(®), and KwikPen™...

Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers. Glutaraldehyde (GLA) cross-linking was shown to further increase the thermostability of clade C 16055 NFL trimers and enhance the induction of tier...