The pseudorabies virus (PrV) gene homologous to herpes simplex virus type 1 (HSV-1) UL53, which encodes HSV-1 glycoprotein K (gK), has recently been sequenced (J. Baumeister, B. G. Klupp, and T. C. Mettenleiter, J. Virol. 69:5560-5567, 1995). To identify the corresponding protein, a rabbit antiserum was raised against a 40-kDa glutathione S-transferase-gK fusion protein expressed in Escherichia...

The presence of glucokinase (GK), a critical enzyme controlling glucose homeostasis and particularly liver glucose utilisation in mammals, has long been a matter of debate in avian species as a number of investigators failed to detect glucokinase activity in livers from the chicken and several other avian species. In this study we cloned a partial GK cDNA from mule duck livers and we measured G...

The low-affinity glucose-phosphorylating enzyme glucokinase (GK) is the flux-limiting glucose sensor in liver and -cells of the pancreas. Furthermore, GK is also expressed in various neuroendocrine cell types. This review describes the complex network of GK regulation, which shows fundamental differences in liver and pancreatic -cells. Tissue-specific GK promoters determine a higher gene expres...

We estimated the key molecules related to Type 2 diabetes mellitus (T2DM) in adipose, liver, and muscle tissues, from nonobese diabetic Goto-Kakizaki (GK) rats and their Wistar controls, by computationally analyzing the expression profiles in open source data. With the aid of information from previous reports, Rev-erbα in adipose tissue emerged as one of the most plausible candidates. Here, in ...

Glucokinase (GK) serves as glucose sensor in pancreatic -cells and in other glucose sensor cells in the body. Biochemical genetic studies have characterized many activating and inactivating GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or diabetes, all inherited as autosomal dominant traits. Mathematical modeling of the kinetic data of recombinant human wil...

The monomeric enzyme GK (glucokinase) has a low affinity for glucose and, quantitatively, is largely expressed in the liver and pancreatic beta-cells, playing a key 'glucose sensing' role to regulate hepatic glucose balance and insulin secretion. Mutations of GK in man can be inactivating, to cause a form of diabetes mellitus, or activating, to lower blood glucose levels. Recently, models of GK...

Let X be a 1-connected space with the homotopy type of a CW -space and H a finite group acting freely on X by homeomorphisms homotopic to the identity. We prove that lkη∗Gk(X) ⊆ Gk(X/H) for all k > 1 and some estimated positive integer lk which depends on k, where Gk is the k′th Gottlieb group and η : X → X/H is the quotient map to the orbit space X/H. We show that lk is independent of k for X ...

A shape invariant model for functions f1,...,fn specifies that each individual function fi can be related to a common shape function g through the relation fi(x)=aig(cix + di) + bi. We consider a flexible mixture model that allows multiple shape functions g1,...,gK, where each fi is a shape invariant transformation of one of those gk. We derive an MCMC algorithm for fitting the model using Baye...

The resting K+ conductance (GK,r) of locust jumping muscle and its modulation by two neuropeptides, proctolin (Arg-Tyr-Leu-Pro-Thr) and YGGFMRFamide (Tyr-Gly-Gly-Phe-Met-Arg-Phe-NH2), were investigated using the two-electrode voltage clamp. At a physiological [K+]o of 10 mM, GK,r accounts for approximately 90% of the membrane resting conductance, and the resting membrane potential differs by </...

We classify finite-dimensional Nichols algebras over finite nilpotent groups of odd order in group-theoretical terms. The main step is to show that the conjugacy classes such are either abelian or type C; this property also holds for finitely generated whose torsion has order. To extend our approach setting GK-dimension, we propose a new Conjecture on racks C. prove bosonization algebra Yetter-...