نتایج جستجو برای: gilford progeria syndrome
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The nuclear morphology of eukaryotic cells is determined by the interplay between lamina forming skeleton, chromatin inside nucleus, and coupling with cytoskeleton. Nuclear alterations are often associated pathological conditions as in Hutchinson-Gilford progeria syndrome (HGPS), which a mutation lamin A gene yields an altered form protein, named progerin, aberrant shape. While genetic molecula...
Hutchinson-Gilford progeria syndrome (HGPS) is a segmental progeroid syndrome with multiple features suggestive of premature accelerated aging. Accumulation of progerin is thought to underlie the pathophysiology of HGPS. However, despite ubiquitous expression of lamin A in all differentiated cells, the HGPS mutation results in organ-specific defects. For example, bone and skin are strongly affe...
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