Daniel T. Kaplan,1,2 John R. Clay,3,4 Timothy Manning,1 Leon Glass,1,2 Michael R. Guevara,1,2 and Alvin Shrier2,4 1Centre for Nonlinear Dynamics, McGill University, Montreal, Quebec, Canada H3G 1Y6 2Physiology Department, McGill University, Montreal, Quebec, Canada H3G 1Y6 3Laboratory of Neurophysiology, National Institutes of Health, Bethesda, Maryland 20892 4Marine Biological Laboratory, Wood...

statement of the problem: soft tissue reactive lesions are the most common lesions of the oral cavity. although many studies have shown the interaction of mast cells with fibroblasts and their participation in fibrosis, the role of mast cells in these lesions is not well understood. purpose: the aim of this study was to evaluate the mast cells (mcs) count in oral soft-tissue reactive lesions in...

Trophoblast giant cells are located at the maternal-embryonic interface and have fundamental roles in the invasive and endocrine phenotypes of the rodent placenta. In this report, we describe the experimental modulation of trophoblast stem cell and trophoblast giant cell phenotypes using the Rcho-1 trophoblast cell model. Rcho-1 trophoblast cells can be manipulated to proliferate or differentia...

p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions. Many GCs exhibited HuD and NeuN immunolabeling suggesting a differentiated neural ...

Nine patients with advanced cancer who were receiving the methanol extraction residue of BCG (MER-BCG) intradermally or intratumorally underwent biopsies from the injected sites or from locally enlarged lymph nodes. Most preparations showed a chronic granulomatous reaction consisting of lymphocytes, histiocytes, and epithelioid cells as well as either Langhans's or foreignbody type giant cells,...

Mouse trophoblast giant cells undergo successive rounds of DNA replication resulting in amplification of the genome. It has been difficult to determine whether giant cell chromosomes are polyploid as in liver cells or polytene as in Dipteran salivary glands because the chromosomes do not condense. We have examined the pattern of hybridization of mouse giant cells with a variety of in situ chrom...

A 70 year old female underwent a hysterectomy due to a diagnosis of high grade endometrioid adenocarcinoma. Pathological examination revealed a Malignant Mixed Mullerian Tumor (MMMT) along with a conventional endometrioid adenocarcinoma with a component of giant cell carcinoma. Giant cell carcinoma of the endometrium is a rare tumor consisting of sheets of discohesive appearing cells with numer...

Sudden cardiac deaths due to giant cell myocarditis (GCM) are uncommon. Giant cell myocarditis is an inflammatory myocardial disease. It is characterized by inflammation of the heart muscle (myocardium), a condition referred to as myocarditis. Inflammation is caused by widespread infiltration of giant cells associated with other inflammatory cells and cardiac muscles cell destruction. Giant cel...

Giant cell carcinoma of the endometrium is a rare and an aggressive tumor that should be distinguished from other endometrial tumors with a prominent giant cell component, including trophoblastic tumors, certain primary sarcomas, and malignant mixed müllerian tumors. At present, cumulative data on this rare histological variant is limited and the prognostic significance of the presence and the ...

an adult female budgerigar (melopsittacus undulatus) presented with abdominal enlargement. the condition of the bird deteriorated after needle aspiration for cytological examination. the budgerigar was euthanatized and a complete necropsy was performed. microscopic sections were prepared and stained with hematoxylin and eosin, gram staining, periodic acid-schiff (pas) and acid-fast staining. es...