نتایج جستجو برای: genotype frequency
تعداد نتایج: 565280 فیلتر نتایج به سال:
Introduction: Based on data from recent trials, peginterferon and ribavirin combination therapy is the standard of care in treating patients with chronic HCV infection, but because of high costs, many patients may deprive from treatment. Methods: We conducted a clinical trial on HCV patients in Yazd in gastroenterology clinic. Thirty patients received conventional subcutaneous interferon alf...
OBJECTIVE This study aims to investigate the association of neonatal indirect hyperbilirubinemia in exclusively breast-fed infants with UGT1A1 (Uridine Diphosphate-Glucuronyl transferase 1A1) polymorphism. METHODS 50 neonates were classified into 2 groups: 1) 30 full term neonates with indirect hyperbilirubinemia (gestational age (GA) 39.5 ± 1.2 weeks); 2) 20 apparently healthy full-term neon...
OBJECTIVE The aim of the present study was to investigate whether there was any relationship between some DNA N-methyltransferase 1 (DNMT1) polymorphisms and susceptibility to idiopathic sudden sensorineural hearing loss (ISSHL) in ISSHL patients. MATERIAL AND METHODS We investigated 90 patients diagnosed with ISSHL and a control group composed of 75 age- and gender-matched healthy individual...
aim : the aim of this study is to investigate the molecular identification of giardia lamblia in patients with diarrhea. background : giardiasis caused by giardia lamblia is a common intestinal disease. although this parasitic infection found in mammals including human, pets and livestock, but few species within the genus giardia can infects humans. g. lamblia have seven complex genotypes terme...
Previous evidence has demonstrated that chemical classes of pesticides, including organophosphates (OP), can induce oxidative stress in exposed workers. The resulting increase in free radicals causes damage to biological macromolecules, and promotes the formation of novel compounds, including advanced glycation end products (AGE) and advanced oxidation protein products (AOPP). The present study...
TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men
The aim of the study is to investigate the association between the human hepatocyte nuclear factor 4 gamma (HNF4G) gene and hyperuricemia in Chinese Han population. A total of 414 hyperuricemia patients and 406 gender and age-matched normouricemic controls were enrolled. Four single nucleotide polymorphisms were genotyped as genetic markers for the human HNF4G gene (rs2977939, rs1805098, rs2941...
BACKGROUND Colorectal cancer (CRC) represents one of the most common malignancies worldwide. Research has indicated that functional gene changes such as single nucleotide polymorphism (SNP) influence carcinogenesis and metastasis and might have an influence on disease relapse. The aim of our study was to evaluate the role of SNPs in selected genes as prognostic markers in resectable CRC. PATI...
Objective: Single nucleotide polymorphism (SNP) in the promoter region of tumor necrosis factor-α (TNF-α) is found to be related to some inflammations and tumors. In this study, we aimed to confirm the correlation between TNF-α-308G/A polymorphism and susceptibility to primary lung cancer among Chinese population. Method: Genotyping was performed for TNF-α-308G/A polymorphism (rs1800629 locus) ...
Rapidly improving high-throughput sequencing technologies provide unprecedented opportunities for carrying out population-genomic studies with various organisms. To take full advantage of these methods, it is essential to correctly estimate allele and genotype frequencies, and here we present a maximum-likelihood method that accomplishes these tasks. The proposed method fully accounts for uncer...
Dispersal is a crucial factor in natural evolution, since it determines the habitat experienced by any population and defines the spatial scale of interactions between individuals. There is compelling evidence for systematic differences in dispersal characteristics within the same population, i.e., genotype-dependent dispersal. The consequences of genotype-dependent dispersal on other evolution...
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