An important everyday task for geneticists and molecular biologists is that of isolating and analyzing some particular DNA regions (markers), each drawn from a limited and known set of possible values (alleles). This procedure is called genotyp-ing and is based on DNA ampliication and size separation. In order to increase the throughput of genotyping, recently a new experiment has been proposed...

Increasing evidence suggests that the insulin-like androgenic gland hormone (IAG) gene plays an important role in male sexual differentiation, metabolism, and growth in crustaceans. In the present study, we isolated the full-length genome sequence of IAG by genome walking based on the cDNA sequence in Macrobrachium nipponense. Four novel single nucleotide polymorphisms (SNPs) were studied, incl...

The GRIN technologies (-geno, -robo, -info, -nano) promise to change the inner constitution of human body and its own existence. This transformation involves the structure of our lives and represent a –brave?– new world that we have to explore and to manage. In this sense, the traditional tools of humanism seems very inadequate to think the biotech century and there is a strong demand of a new ...

Source/description: Porcine chromosome 8 is homologous to human chromosome 4, but a significant number of rearrangements in gene order exist when compared with human. Genes expected to linkage map specifically in quantitative trait loci (QTL) regions for uterine capacity and ovulation rate were chosen by their position on human chromosome 4 (UCSC version hg16 based on NCBI Build 34; Golden Path...

In the present investigation 28 genotypes of soybean were analysed using 37 start codon targeted (SCoT) markers and primers produced 260 DNA fragments with an average 7.03 bands per primer. From these primers, SCoT 33 65 wos most polymorphic, where 10 polymorphic amplification products detected. The lowest number amplified (2) was detected by 8, 14, 19, 31 59. Of bands, 200 (77.27 %) 5.41 To de...

Letermovir is a novel antiviral compound currently in clinical development for the prevention of human cytomegalovirus (HCMV) infections. In contrast to all currently approved anti-HCMV drugs that target the viral DNA polymerase, letermovir acts via a distinct mode of action involving the viral terminase subunit pUL56. To extend our understanding of potential letermovir resistance mechanisms, w...

Mojamoja (angl. moyamoya) liga (MML) yra lėtinis obstrukcinis smegenų kraujotakos sutrikimas, kuriam būdingas laipsniškas vidinės miego arterijos termina­linės dalies susiaurėjimas ir neįprasta pamato kraujagyslių struktūra. Nors etiologija tiksliai nežinoma, genetiniai tyrimai rodo RNF213 geno svarbą. Liga labiau paplitusi Rytų Azijos šalyse. Vyrauja ryškesnės amžiaus paplitimo grupės: maždaug...