This article presents a genetic algorithm modification inspired by events related to great extinctions. The main objective of the was minimize number function solutions until minimum for established. It assumed that, within each step, population should be smaller than that recommended in applicable literature, iterations limited, solution area variable, and extinction event take place following...

This year marks the 48th anniversary of Francis Crick's seminal work on the origin of the genetic code, in which he first proposed the "frozen accident" hypothesis to describe evolutionary selection against changes to the genetic code that cause devastating global proteome modification. However, numerous efforts have demonstrated the viability of both natural and artificial genetic code variati...

Genetic modification of crop plants has promoted concerns about potential environmental effects of this new technology. In this essay, I will discuss the environmental effects of genetic modification of crop plants using herbicide resistance as an example. Considering herbicide resistance as an old agricultural trait, it is difficult to find any reason to assess the environmental risks of genet...

Asymmetrical responses were obtained in a replicated study of 15 generations of two-way selection for recombination rate between the ruby (rb) and jet (j) loci in Tribolium castaneum. Recombination rates in the two replicate high lines increased from an average of 0.22 in the base populations to an average of 0.42 at generation 15. Recombination rate pooled over the 15 generations of selection ...

The original rationale and impetus for artificial genetic modification was the “central dogma” of molecular biology that assumed DNA carries all the instructions for making an organism, which are transmitted via RNA to protein to biological function in linear causal chains. This is contrary to the reality of the “fluid genome” that has emerged since the mid-1970s. In order to survive, the organ...

Recombination clusters nonuniformly across mammalian genomes at discrete genomic loci referred to as recombination hotspots. Despite their ubiquitous presence, individual hotspots rapidly lose their activities, and the molecular and evolutionary mechanisms underlying such frequent hotspot turnovers (the so-called "recombination hotspot paradox") remain unresolved. Even though some sequence moti...

Effective population size (Ne) is a single number which allows us to relate a large part of population-genetics theory built around ideal populations to real populations. In the case of Anopheles gambiae, Ne is important to interpreting the temporal and spatial distribution of genes. These patterns are in turn used to explore the structure of (typically non-ideal) natural populations. We discus...