نتایج جستجو برای: genetic disorder
تعداد نتایج: 1161670 فیلتر نتایج به سال:
Validity of the current diagnostic distinction of bipolar affective disorder and schizophrenia in classification systems ICD-10 and DSM IV is challenged by an accumulating amount of various independent findings. The authors review the similarities and distinctions beetween both disorders in a range from psychopathology to neuroimaging methods. An emphasis is given on genetic findings as a major...
Bipolar affective disorder and schizophrenia share many clinical and genetic characteristics, and are thought by some to be different expressions of the same underlying disorder. A recent study showed an excess of homozygosity at a BalI polymorphism in the dopamine D3 receptor gene in schizophrenic patients compared with controls, from two independent centres. We have found no evidence of such ...
Bipolar disorder is a common, complex psychiatric disorder characterized by mania and depression. The disease aggregates in families, but despite much effort, it has been difficult to delineate the basic genetic model or identify specific genetic risk factors. Not only single gene Mendelian transmission and common variant hypotheses but also multivariate threshold models and oligogenic quasi-Me...
BACKGROUND Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to know whether any of the various diagnostic categories in current use identify cases that are particularly helpful for biological-genetic research. AIMS To use genome-wide genetic association data to explore the relative genet...
Autism spectrum disorder (ASD) is characterized by qualitative impairments in social interaction, communication, and stereotyped behavior patterns. The cost burden for health coverage ASD focused on educational applied behavioral analysis psychotropic drugs to decrease maladaptive behaviors support learning development. Determinants of either risk factors or prevention related covering environm...
OBJECTIVES Bipolar disorder is associated with elevated risk of suicide attempts and deaths. Key aims of the International Society for Bipolar Disorders Task Force on Suicide included examining the extant literature on epidemiology, neurobiology and pharmacotherapy related to suicide attempts and deaths in bipolar disorder. METHODS Systematic review of studies from 1 January 1980 to 30 May 20...
Alcoholism is a complex disorder involving both genetic and environmental factors and interactions between them. Localizing and characterizing the genetic influences on susceptibility to alcohol dependence may provide new insights into pathology and new avenues for treatment and prevention. However, because of the complex nature of the disorder, the binary categorization of individuals as affec...
Sotos syndrome is a genetic disorder characterized by overgrowth, megalocephaly, and mental retardation due to mutations or deletions in the nuclear receptor binding SET Domain protein 1 (NSD1) gene. We report case of with various oral symptoms.
Background Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder that affects 8-12% of school-age children. Several environmental and genetic factors play a role in the etiology of this disease. One of the genetic factors involved is dopamine beta-hydroxylase (DBH) gene, which plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine...
OBJECTIVE Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There is evidence that aggression or conduct disorder in children with ADHD indexes higher genetic loading and clinical severity. The authors examine whether common genetic variants considered ...
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