aim : the aim of this study was to evaluate the likelihood ratio and frequency of dq2 and dq8 in iranian patients with celiac disease (cd). background : the hla dq2 and hla dq8 are the important mediators in the development of celiac disease. a few studies evaluated the frequency of hla dq2 and hla dq8 haplotypes among the iranian population with low sample size. patients and methods : in this ...

In this paper, we develop mathematical machinery for verifying that a broad class of general state space Markov chains reacts smoothly to certain types of perturbations in the underlying transition structure. Our main result provides conditions under which the stationary probability measure of an ergodic Harris recurrent Markov chain is diierentiable in a certain strong sense. The approach is b...

In instantaneous encephalogram or magnetoencephalogram (EEG/MEG) source analysis, ordinary least squares estimation (OLS) requires that the spatial noise is homoscedastic and uncorrelated over sensors. In spatio-temporal analysis OLS also requires that the noise is homoscedastic and uncorrelated in time (over samples). Generally, these assumptions are violated and, as a consequence, OLS can giv...

Additive models with backfitting algorithms are popular multivariate nonparametric fitting techniques. However, the inferences of the models have not been very well developed, due partially to the complexity of the backfitting estimators. There are few tools available to answer some important and frequently asked questions, such as whether a specific additive component is significant or admits ...

Composite likelihood may be useful for approximating likelihood based inference when the full likelihood is too complex to deal with. Stemming from a misspecified model, inference based on composite likelihood requires suitable corrections. Here we focus on the composite likelihood ratio statistic for a multidimensional parameter of interest, and we propose a parameterization invariant adjustme...

2000 We extend the Semiparametric Likelihood Ratio Theorem of Murphy and Van del' Vaart for one-dimensional to Euclidean paramet(;rs of auy dimension. The as:VIrlptotic distribution of the likelihood ratio statistic for testing a k-dimensional Euclidean paramet'"r is shown to be the usual under the null hypothesis. This result is useful not only for testing purposes but also in forming likeliho...

The generalized likelihood ratio (GLR) statistic (Fan, Zhang, and Zhang (2001)) offered a generally applicable method for testing nonparametric hypotheses about nonparametric functions, but its efficiency is adversely affected by outlying observations and heavy-tailed distributions. Here a robust testing procedure is developed under the framework of the GLR by incorporating a Wilcoxon-type arti...