background: acute promyelocytic leukemia (apl) is a unique subtype of acute leukemia. apl is a curable disease; however, drug resistance, early mortality, disease relapse and treatment-related complications remain challenges in apl patient management. one issue underlying these challenges is that the molecular mechanisms of the disease are not sufficiently understood. materials and methods: in ...

conjugated linoleic acids (cla) are natural constituents of meat and dairy products from ruminants, originating from bacterial biohydrogenation in the rumen. cla supplementation increases the health benefits of animal-derived foods. there are inconsistent reports of the effects of dietary cla on chicken’s performance; however, the majority of previous reports cite anti-lipogenic effects of cla....

objective: in this study quantitative expression of mdr1 and hoct1 genes in cml patients and normal people were measured using real-time pcr. materials and methods: to study quantitative expression of these genes by real-time pcr, master-mix with syber green was used. peripheral blood samples from 30 cml patients and 27 normal persons were harvested. real-time pcr results were analyzed with re...

plasma membrane h+-atpase is a major integral membrane protein with a role in various physiological processes including abiotic stress response. to study the effect of nacl on the expression pattern of a gene encoding the plasma membrane h+-atpase, an experiment was carried out in a completely random design with three replications. a pair of specific primers was designed based on the sequence o...

conclusions traf6 plays an important role in the onset of colon cancer; therefore, drugs targeting it may have great clinical significance in the treatment of this disease. results the positive expression rate of traf6 in tumor tissues was 66.7%, which was significantly higher than in normal paracancerous tissues (18.5%). the positive expression rate of traf6 was significantly correlated with d...

background resistance exercise is recommended as a useful therapeutic tool for the treatment of type 2 diabetes (t2d); however, the frequency of studies is inadequate to establish the precise mechanisms of any association between them. objectives in this study, we aimed to assess the effect of three months of resistance training on tcf7l2 expression in pancreatic tissues, serum insulin and gluc...

background cucumber mosaic virus (cmv) has isometric particles with a diameter of about 28–29 nm. a useful method to recognize regions from mutagenesis in the coat protein (cp) gene are important for particle assembly and the expression of viral in cp expression systems like bacteria such as e.coli or yeast as well as their assembly into virus-like particles (vlp). objectives in this paper, we ...

Background & Aims: Atherosclerosis is a major cause of morbidity and mortality. Adiponectin reducesthe risk of heart disease, and matrix metalloproteinase-9 (MMP-9) is involved in the formation and development of atherosclerotic plaque. The aim of this study was the investigation of the effect of adiponectin on MMP-9 gene expression. It seems this hormone can reduce the risk of atherosclerosis ...

Most plants encounter stress such as drought and salinity that adversely affect growth, development and crop productivity. The expression of the gene glutathione-s-transferases (GST) extends throughout various protective mechanisms in plants and allows them to adapt to unfavorable environmental conditions. GSTF1 (the first phi GSTFs class) gene expression patterns in the wheat cultivars Mahuti ...