Prenylated Rab GTPases cycle between membrane-bound and soluble forms. Membrane-bound GDP-Rabs interact with GDP dissociation inhibitor (GDI), resulting in the dissociation of a Rab.GDI complex, which in turn serves as a precursor for the membrane re-association of Rabs. We have now characterized the binding of Rab3A to synaptic vesicles in vitro using either purified complexes or rat brain cyt...

We present a machine learning approach for the Arabic Dialect Identification (ADI) and the German Dialect Identification (GDI) Closed Shared Tasks of the DSL 2017 Challenge. The proposed approach combines several kernels using multiple kernel learning. While most of our kernels are based on character p-grams (also known as n-grams) extracted from speech transcripts, we also use a kernel based o...

Glaucoma drainage implants (GDIs) are used to treat paediatric glaucoma resistant to conventional medical and surgical treatment, achieving good intraocular pressure (IOP) control and long-term success. Late endophthalmitis is a rare complication that may develop following GDI surgery. A 17-year-old male presented with acute endophthalmitis 2 years after Ahmed glaucoma valve implantation with p...

The factorstructure of theChildren's Depression Inventory (GDI), the most widely used self-report measure of depression for children, has been studied, but we still know relatively little about how developmental differences relate to CD1 structure. Here, we evaluated whether the GDI factor structure differed in large samples of clinic-referred children versus adolescents. Our results indicated ...

This paper gives an overview of the potential of the current implementation of portable components for Geoscientific Information Systems (GIS) within the GISIG actmap-project. The computing problems addressed are multifold and for the first time presented here: With Active Source having extended the framework for conventional GIS, new features have been enabled like the use of Grid Computing an...

Post-translationally isoprenylated proteins represent major hubs in most membrane-connected signaling networks. GDP dissociation inhibitors (GDIs) are molecular chaperones that shuttle geranylgeranylated GTPases between membranes and the cytosol. Despite numerous studies, the mechanism of targeted membrane delivery of GTPases remains unknown. Here we have combined chemical synthesis and express...

The logic gates are the fundamental building blocks of VLSI and embedded applications. These gates can be designed using several design techniques and implemented at different levels of architectures. This paper focuses on design and evaluate the performance of logic gates used in the Adders and Multiplier using various design technique like CMOS design GDI design and PTL design. These differen...