OBJECTIVE there are many questions and little evidence regarding the diagnosis and treatment of gastroesophageal reflux disease (GERD) in children. The association between GERD and cow's milk protein allergy (CMPA), overuse of abdominal ultrasonography for the diagnosis of GERD, and excessive pharmacological treatment, especially proton-pump inhibitors (PPIs) are some aspects that need clarific...

BACKGROUND & AIMS A history of high body mass index (BMI) is associated strongly with a risk of esophageal adenocarcinoma (EAC). We investigated whether gastroesophageal reflux is involved in this association. METHODS We analyzed data from a population-based Swedish nationwide study of patients with a new diagnosis of EAC (n = 189) or gastroesophageal junction adenocarcinoma (n = 262), and ma...

OBJECTIVES To review the literature on the treatment of gastroesophageal reflux disease (GERD) with emphasis on pharmacological aspects. To identify particularities of pharmacological treatment of esophageal and extraesophageal manifestations of the disease. SOURCES Electronic search of the PubMed/MEDLINE and Cochrane Collaboration databases. Controlled and randomized studies published since ...

Gastroesophageal reflux disease (GERD) is a chronic condition requiring long-term treatment. Simple lifestyle modifications are the first methods employed by patients and, because of their low cost and simplicity, should be continued even when more potent therapies are initiated. Potent acid-suppressive therapy is currently the most important and successful medical therapy. Whereas healing of t...

Evidence-Based Answer Proton pump inhibitors (PPIs) are superior to histamine H2 antagonists for treating chronic GERD. Comparisons among different PPIs or among different dosages and dosing regimens show few consistent differences. Limited studies suggest that continuous daily dosing provides improved symptom control and quality of life at six months compared with on-demand dosing. Surgery app...