WIZRTHER, J. LAWRENCE, AND FRANKLIN HOLLANDER. Potassium in mecholyl-stimulated gastric secretion in the dog. Am. J. Physiol. 202(4) : 72 1-724. 1962. Previous work indicated that K concentration ([K]) of gastric juice rises abruptly after histamine injection, concomitantly with acid efflux. Using Heidenhain and vagal pouch dogs, these experiments (26 in all) were repeated with mecholyl and his...

The nature of hypersecretion of gastric acid in duodenal ulcer subjects remains controversial. The duodenal ulcer patients, on an average, secrete more than twice the amount of acid secreted by normal persons. It is now known that the duodenal ulcer patients have an increased parietal cell population in the stomach. Whether this increased acid output is solely due to the increased parietal cell...

Na-K-2Cl cotransporter-1 (NKCC) has been detected at exceptionally high levels in the gastric mucosa of several species, prompting speculation that it plays important roles in gastric secretion. To investigate this possibility, we 1) immunolocalized NKCC protein in the mouse gastric mucosa, 2) compared the volume and composition of gastric fluid from NKCC-deficient mice and their normal litterm...

Intraduodenal infusion of increasing amounts of hydrochloric acid solution results in a stepwise increase in the volume of pancreatic secretion and output of bicarbonate, reaching about 90% of amounts attained with exogenous secretin infused intravenously in increasing doses. Acid infusion into the different regions of the intestine stimulates pancreatic secretion only from the duodenum and upp...

EDITORIAL SYNOPSIS The long-held view that body build could be related to gastric secretion and a diathesis to the development of gastric or duodenal ulcer seems to have been disproved by this careful study, in which the peak acid output of the augmented histamine test could not be correlated with body weight, surface area, or linearity in a group of normal and ulcer subjects. Re-examination of...

Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti - secretory activity in pylorus ligated rats and cats. In lumen - perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA - induced back - dif...

In order to evaluate the incidence and aetiology of hypergastrinaemia 53 patients with seropositive rheumatoid arthritis were examined for gastric acid secretion, fasting serum gastrin concentration, circulating parietal cell antibodies, and some parameters of the activity of inflammation of rheumatoid arthritis. The basal and maximum acid output was found to be subnormal in this group (P less ...

Vagotomy, combined with a drainage procedure, has become increasingly popular in the surgical treatment of chronic duodenal ulcer. After operation the nervous phase of gastric secretion is abolished and the maximum secretory response to histamine, varying in degree from 70% (Falconer, 1959) to 80 %, (Gillespie, Clark, Kay, and Tankel, 1960) is reduced. The role of the vagus nerves in gastric se...

OBJECTIVES Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors in response to mucosal acidification and distention-induced gastric acid sec...