The chronic keratitis resulting from the steroid treatment of acute herpes simplex infection of the rabbit cornea was significantly improved by the subconfunctival administration of either human or rabbit gamma globulin, the latter possessing no neutralizing antibody to herpes simplex virus. Virus titrations of this late lesion were consistently negative. The etiological and therapeutic implica...

Ziff, Schmid, Lewis, and Tanner (1958) first reported that rheumatoid factors reacting with human Cohn fraction II gamma globulins assessed by means of a latex-fixation test (LEI) were aggregated in the families of hospital patients with rheumatoid arthritis. This evidence for familial aggregation was confirmed by Ball and Lawrence (1961) in the urban population sample of Leigh, England, the te...

BACKGROUND Developing world are always looking for monitoring tools during reagent shortage and equipments troubles which are very frequent. The aim of this study was to evaluate Serum Protein Electrophoresis (SPE) as a marker for assessing HIV treatment response. METHODS A cross-sectional study was conducted with 220 participants in four distinct groups: Symptomatic HIV positive patients [sp...

Recent studies have demonstrated that the factors responsible for the various serological reactions currently employed for the diagnosis of rheumatoid arthritis represent macroglobulins which, in the isolated state, have a corrected sedimentation coefficient of approximately 19S (1-5). In serum and plasma, these proteins exist as complexes with low molecular weight y-globtulins and show a highe...

A simple anti-gamma-globulin consumption test for use in suspected Hashimoto's disease is described. Results in cases with positive and negative tanned red-cell tests are described.

Beta-2A globulin and the 7S and 19S gamma globulins are the major proteins of the serum derived from the immune system. Collectively they have been termed the immunoglobulins. The 19S gamma globulin, also known as the gamma-1 macroglobulin, the 82 macroglobulin or 82M, has been the subject of intensive study in recent years. The rheumatoid factor as well as a variety of anti-bodies fall into th...

A high incidence of acute diffuse glomerulitis was produced in unilaterally nephrectomized rabbits by injection with two successive doses of purified bovine serum gamma globulin (fraction II). This experimental nephritis is morphologically analogous to human acute and subacute diffuse glomerulonephritis. The technique described is advanced as a valuable experimental method in the study of the p...

A marked increase of the serum beta globulins was found in rabbits developing amyloidosis as a result of prolonged treatment with ribonucleate administered by subcutaneous injections. Following cessation of treatment the beta globulin levels gradually returned to normal while the gamma globulin levels rose strikingly, the changes being accompanied by a resorption of amyloid from the spleen, and...