ABSTRACT The efficacy of gamma irradiation is well versed as a method of decontamination for food and herbal resources. In the present study, Cichorium intybus L. roots were irradiated at multiple doses of 1, 2, 4, 6, 8 and 10 kGy by a cobalt-60 irradiator. The irradiated and non-irradiated control samples were evaluated for total phenolic contents, chlorogenic acid assay, 2,2-diphenyl-1-...

Background: Although numerous natural or synthetic drugs have been tested for their radioprotective capacity, yet no suitable drug has been introduced for routine clinical use. In this study the radioprotective effect of "a new herbal immunomodulator" commercially known as IMOD, specifically made to decrease the side effects of HIV virus, was investigated on mouse bone marrow cells. M...

Introduction: Interactions of free radicals from ionizing radiation with DNA can induce DNA damage and lead to mutagenesis and carsinogenesis. With respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation. In the present study,the effects of arbutin were investigated by using the micronucleus test for anti- clastog...

Gamma radiation produces free radicals when interacting with cells. The radical can be neutralized and caught by an antioxidant compound. This research aimed to analyze the effect of gamma exposure treated Curcuma xanthorrhiza extract capsules on cells damage mice’s liver. study used mice Balb/c strain average body weight 18-20 grams, aged 6-8 weeks male. required 80 animals for 3 groups, namel...

Based on experiments with mouse cells, it appears that macrophage activation for cytotoxicity requires two exogenous signals. One signal primes or sensitizes the cells, while the second activates them for killing. The present studies were designed to analyze the capacity of rat macrophages to be activated for nitric oxide production and for cytotoxicity by different inflammatory stimuli. We fou...

Background: Previous investigations have revealed, cimetidine, a histamine H2-receptor antagonist, show radioprotective effects against gammaand neutron-induced micronuclei in bone marrow erythrocytes. In this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine H2-receptor antagonists, was investigated. Materials and Methods: Balb/c male...

Alfalfa in dry stress conditions cannot grow optimally. Drought inhibits growth and reduces alfalfa production many cultivation systems. Plants breeding with gamma-ray irradiation vitro selection using PEG found somaclonal variants adapted to well drought conditions. This study aims determine the type of mutation best morphology mutants resulting from gamma were sub-cultured vitro. cultured med...

Gamma-Knife became an established therapeutic alternative for selected cases of vestibular schwannomas (benign tumors rooting from Scwann cells of vestibular nerve). However, the long term results and effects on the tumor and surrounding brain are still a matter of research. We analyze the imagistic findings in the patients with vestibular scwannomas treated with gamma-knife radiosurgery in the...