نتایج جستجو برای: gadd45a
تعداد نتایج: 375 فیلتر نتایج به سال:
Understanding processes regulating prostate cancer cell survival is critical to management of advanced disease. We used prostate cancer cell transfectants genetically modified to be deficient in either endogenous fibroblast growth factor (FGF-1) or endogenous FGF-2 to examine FGF maintenance of transfectant survival and proliferation and FGF-2-regulated expression of transfectant growth arrest ...
UNLABELLED To successfully replicate in an infected host cell, a virus must overcome sophisticated host defense mechanisms. Viruses, therefore, have evolved a multitude of devices designed to circumvent cellular defenses that would lead to abortive infection. Previous studies have identified Nek9, a cellular kinase, as a binding partner of adenovirus E1A, but the biology behind this association...
The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular basis for this requirement is unknown. Here we show that a single, conserved NMD target, the mRNA coding for the stress response factor growth arrest and DNA-damage inducible 45 (GADD45) can account for lethality in Drosophila...
Biji Mathew,* Daisuke Takekoshi,* Saad Sammani, Yulia Epshtein, Rajesh Sharma, Brett D. Smith, Sumegha Mitra, Ankit A. Desai, Ralph R. Weichselbaum, Joe G. N. Garcia, and Jeffrey R. Jacobson Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, Illinois; Department of Respiratory Medicine, Tohoku University Hospital, Miyagi, Japan; Department of Ra...
UV radiation-induced mutation of the p53 gene is suggested as a causative event in skin cancer, including melanoma. We have analyzed here p53 mutations in melanoma cell lines and studied its stabilization, DNA-binding activity, and target gene activation by UVC. p53 was mutated in three of seven melanoma cell lines. However, high levels of p53 were detected in all cell lines, including melanoma...
Hydrogen (H2) is a major biodegradation product of implanted magnesium (Mg) alloys that are commonly used in the healing bone fractures. Our earlier study showed H2 can inhibit mouse marrow mononuclear cell (BMMC) osteoclastogenesis during differentiation these cells into osteoclasts, thereby facilitating fracture healing. However, way by which H2 inhibits remains to be el...
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