Callera, João Carlos, Leni G. H. Bonagamba, Anne Nosjean, Raul Laguzzi, and Benedito H. Machado. Activation of GABAA but not GABAB receptors in the NTS blocked bradycardia of chemoreflex in awake rats. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1902–H1910, 1999.—In the present study we analyzed effects of bilateral microinjections of muscimol (a GABAA agonist) and baclofen (a GABAB agonist...

Adenosine is a powerful central neuromodulator acting via opposing A1 (inhibitor) and A2a (activator) receptors. However, in the nucleus of the solitary tract (NTS), both adenosine receptor subtypes attenuate cardiopulmonary chemoreflex (CCR) sympathoinhibition of renal, adrenal, and lumbar sympathetic nerve activity and attenuate reflex decreases in arterial pressure and heart rate. Adenosine ...

INTRODUCTION y-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. It mediates its effects via the specific interaction with the integral membrane proteins, the GABA receptors. GABA receptors can be classified according to their respective transduction mechanisms following activation, as the GABA and the GABAB receptor respectively. The focus of this review...

introduction: the bed nucleus stria terminalis (bst) is a part of the limbic system. it was recently shown that chemical stimulation of the bst by l-glutamate elicited cardiovascular depressive responses. in the present study, we have investigated the possible cardiovascular role of the gabaergic receptors in bst by microinjection of its agonist and antagonists. methods: experiments were perfor...

Introduction: The present study investigated the interactive effect of GABAB receptors and extremely low frequency electromagnetic field (ELF-EMF) on foot shock-induced aggression in rats. Methods: fifty adult male rats were randomly assigned into 10 groups. Groups 2, 4, 6, 8 and 10 were exposed to 50 Hz, 500 µT ELF-EMF for 30 days 8h per day while the remaining groups (1, 3, 5, 7 and 9) were...

Degeneration of dopamine (DA) neurons in Parkinson's disease (PD) causes hypokinesia, but DA replacement therapy can elicit exaggerated voluntary and involuntary behaviors that have been attributed to enhanced DA receptor sensitivity in striatal projection neurons. Here we reveal that in hemiparkinsonian mice, striatal D1 receptor-expressing medium spiny neurons (MSNs) directly projecting to th...

Antibody-mediated autoimmune encephalopathies comprise a group of severe conditions with a varying degree of motor and cognitive symptoms that respond to immunotherapies. The associated antibodies are directed against intracellular targets, such as the classic paraneoplastic autoantigens Hu, Yo, Ri, CV2, Ma2/Ta, or the enzyme GAD, or against cell surface antigens such as receptors and ion chann...

The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallidus, vestibular and spinal trigeminal nuclei, and the CA3 region of the hippoca...

The actions of the anticonvulsant gabapentin [1-(aminomethyl)cyclohexaneacetic acid, Neurontin] have been somewhat enigmatic until recently, when it was claimed to be a -aminobutyric acid-B (GABAB) receptor agonist acting exclusively at a heterodimeric complex containing the GABAB(1a) splice variant (Mol Pharmacol 2001;59:144–152). In this study, we have investigated the effects of gabapentin o...