Isogenic lines, in which chromosomes sampled from natural populations of C. melanogaster are substituted into a common genetic background, were used to detect and partially characterize autosomal factors that affect the activities of the two pentose phosphate pathway enzymes, glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD). The chromosome 3 effects on G6PD a...

background: maternal and neonatal factors could help determine the potential incidence of hyperbilirubinemia. in this study, we aimed to identify the relationship between the severity of jaundice in newborns and maternal and neonatal factors. methods: this descriptive, cross-sectional study was conducted in 2014. icteric newborns, admitted to qods and kowsar teaching hospitals in qazvin, iran w...

in order to explore the nature of glucose-6-phosphate dehydrogenase (g6pd) deficiency in one of the coastal provinces of the caspian sea (mazandaran) in iran, we have analysed the g6pd gene in 74 unrelated g6pd-deficient males (2-6 year children) with a history of favism, by using pcr and subsequent digestion by appropriate restriction enzymes, looking for the presence of certain known mutation...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is probably the most common disease-producing genetic polymorphism of humans. Virtually all G6PD-deficient Africans show the G6PD A- phenotype, an electrophoretically rapid, deficient enzyme. The recently acquired ability to identify the point mutations producing the different variants has given us new insights into the population genetics of ...

Dehydroepiandrosterone (DHEA) and certain structural analogues block the differentiation of 3T3-L1 mouse embryo fibroblasts to adipocytes. These steroids also are potent uncompetitive inhibitors of mammalian glucose-6-phosphate dehydrogenases (G6PDs). We provide direct evidence that treatment of the 3T3-L1 cells with DHEA and its analogues results in intracellular inhibition of G6PD, which is a...