نتایج جستجو برای: fungiform

تعداد نتایج: 360  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Archana Kumari Alexandre N Ermilov Marina Grachtchouk Andrzej A Dlugosz Benjamin L Allen Robert M Bradley Charlotte M Mistretta

Striking taste disturbances are reported in cancer patients treated with Hedgehog (HH)-pathway inhibitor drugs, including sonidegib (LDE225), which block the HH pathway effector Smoothened (SMO). We tested the potential for molecular, cellular, and functional recovery in mice from the severe disruption of taste-organ biology and taste sensation that follows HH/SMO signaling inhibition. Sonidegi...

Journal: :Chemical senses 2005
A San Gabriel H Uneyama S Yoshie K Torii

Monosodium L-glutamate (MSG) functions as a signal for dietary protein. In the tongue, glutamate binds presumably to taste cell chemoreceptors which, upon being activated, alter the firing rate of innervating sensory nerves. It has just recently been hypothesized that several G protein coupled receptors (GPCR) acted as umami receptors (Chaudhari et al., 2000; Li et al., 2002; Nelson et al., 200...

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