The management of invasive fungal infections has been hampered by the inability to make a diagnosis at an early stage of the disease. Molecular diagnosis by PCR appears very promising since fungal DNA can be detected in the blood of infected patients earlier than when using conventional methods. Recently, interest in the diagnosis of invasive fungal infections by real-time PCR has increased. Re...

OBJECTIVE To evaluate the prevalence and factors influencing the presence of concomitant dermatomycoses in patients with toenail onychomycosis. DESIGN Prospective study based on a specially designed questionnaire completed by dermatologists. PATIENTS A total of 2761 patients with toenail onychomycosis. MAIN OUTCOME MEASURES The diagnosis of fungal skin infections was confirmed by direct m...

Fungal infections of the gastrointestinal tract are not common in children, especially in immunocompetent ones. In this case report we describe a child who was presented with abdominal pain and mass, bloody diarrhea and fever. He was treated for amebiasis, but due to treatment failure and deterioration of his condition, he underwent a laparatomy. Histologic examination of the excised bowel in ...

Sixty-two adults who underwent orthotopic liver transplantations between February 1981 and June 1983 were followed for a mean of 170 days after the operation. Twenty-six patients developed 30 episodes of significant fungal infection. Candida species and Torulopsis glabrata were responsible for 22 episodes and Aspergillus species for 6. Most fungal infections occurred in the first month after tr...

Most fungi live harmlessly in the environment, but some species can cause disease in the human host. Nurses working in primary care are likely to see patients with superficial fungal infections and are well placed to offer advice about treatment and measures to prevent the spread of infection in the home. Patients with weakened immune function admitted to hospital are at high risk of developing...

Invasive fungal infections are a major cause of morbidity and mortality in immunocompromised patients. Because the etiologic agents of these infections are abundant in nature, their isolation from biopsy material or sterile body fluids is needed to document infection. This review evaluates and discusses different human body fluids used to diagnose fungal infections.

A STUDY DONE at our institution between 1981 and 1983 showed that 42% of liver recipients developed invasive fungal infections, mostly due to Candida and Aspergillus. l Between July 1984 and September 1985 we studied 101 consecutive adult liver transplant recipients at Presbyterian University Hospital for the incidence and risk factors associated with invasive fungal infection. The risk factors...

Despite greater knowledge and possibilities in pharmacotherapy, fungal infections remain a challenge for clinicians. As the population of immunocompromised patients and those treated for their hematologic ailments increases, the number of fungal infections grows too. This is why there is still a quest for new antifungal drugs as well as for optimization of pharmacotherapy with already registere...

Abstract: Despite several topical and systemic antifungal drugs are used for the treatment of fungal infection, Amphotericin B (AmB) is still one of the most common first-line choices in systemic fungal infection for over seventh decades from discovery. Amphotericin B which is belonged to the polyene group has a wide spectrum in vitro and in vivo antifungal activity. Its mechanism of antifunga...