This research was designed to study the effect of bitter almond oil on the healing of open skin wounds in rats. Thirty female adult rats were randomly divided into experimental (n=15) and control (n=15) groups. Under general anesthesia and sterile conditions, one quadrangular (surface area=22 mm) full thickness skin wound was made on the dorsum of each rat. The day of surgery was considered as ...

Background: It was well known that inhibitory effect of corticosteroids on cutaneous wound healing antagonized by the use of topical tretinoin and systemic vitamin A. However, the exact mechanism of this antagonistic interaction is not yet fully known. The aim of this study was to investigate the effects of topical tretinoin and adapalene application on tissue hydroxyproline content in corticos...

Exogenous nitric oxide donors such as DETA NONOate, spontaneously release nitric oxide. This study aimed to investigate the effect of DETA NONOate as a nitric oxide releasing drug on the rate of collagen synthesis during the impaired wound healing in a rat model of diabetes. Twelve male Sprague–Dawley rats were transferred into separate metabolic cages. Nine days before wounding, the rats were ...

Wound closure with cultured skin substitutes results in epithelium that is consistently hypopigmented. Hypothetically, addition of human melanocytes to cultured skin grafts may result in normal pigmentation of healed skin. Skin substitutes were composed of human epidermal keratinocytes and melanocytes, dermal fibroblasts, and collagen-glycosaminoglycan substrates, and were incubated for 12 d in...

Objective- To evaluate the effects of autologous platelet-rich plasma (PRP) on wound healing in dogs. Design- Experimental in-vivo study. Animals- 5 mix-breed male adult dogs. Procedures- Under general anesthesia, six 2 × 2-cm, full-thickness skin wounds were created on the back of dogs symmetrically. In each dog, three right side wounds were treated topically with 1.5 ml PRP jelly, whereas lef...

BACKGROUND Current use of Integra, the collagen-based dermal analogue, requires a two-step grafting procedure to achieve wound closure with an "ultrathin" autograft. METHODS A one-step operative procedure of meshed composite skin graft (MCSG) using Integra as a dermal template for a meshed split thickness autograft was developed in rats. The silicon layer of Integra was removed, the resulting...

Estrogen promotes cutaneous wound healing in ovariectomized (OVX) female mice. However, the effects of topical estrogen application on wounds remain unclear. Therefore, the aim of this study was to compare the effects of topical estrogen application on wounds with standard treatment methods. Eight-week-old C57BL/6J female mice underwent OVX and received two full-thickness wounds four weeks late...

OBJECTIVE To assess the safety and efficacy of bioengineered skin substitutes in comparison with biological skin replacements and/or standard dressing methods in the management of burns, through a systematic review of the literature. METHODS Literature databases were searched up to April 2006, identifying randomised controlled trials. RESULTS Twenty randomised controlled trials were include...

Dear Sir, The most widely used skin graft in the treatment of full-thickness wounds, caused by major burns or trauma, is split-thickness skin grafts (STSGs). 1-3 In an attempt to increase the expansion ratio of the STSGs, our laboratory has previously shown that autologous minced skin grafting accelerates reepitheliazation. 4-7 The micrografts (0.8 mm × 0.8 mm) are generated by controlled minci...

Despite advances in traumatic wound care and management, infections remain a leading cause of mortality, morbidity and economic disruption in millions of wound patients around the world. Animal models have become standard tools for studying a wide array of external traumatic wound infections and testing new antimicrobial strategies. Study of wound-healing action was conducted on model of full-t...