A rapid tandem mass spectrometric (MS-MS) method for the quantification of Oxcarbazepine (OXB) in human plasma using imipramine as an internal standard (IS) has been developed and validated. Chromatographic separation was achieved isocratically on a C18 reversed-phase column within 3.0 min, using a mobile phase of acetonitrile-10 mM ammonium formate (90 : 10 v/v) at a flow rate of 0.3 ml/min. Q...

This paper explores the role of one-at-a-time experimentation in parameter design of engineering systems. The focus is on degree of improvement achieved rather than on efficiency in estimating model parameters. The performance of adaptive one-at-a-time plans is compared with the performance of orthogonal arrays through computer simulations based on data from 66 response variables in 27 full fac...

Artificial neural networks have been used to support applications across a variety of business and scientific disciplines during the past years. Artificial neural network applications are frequently viewed as black boxes which mystically determine complex patterns in data. Contrary to this popular view, neural network designers typically perform extensive knowledge engineering and incorporate a...

Alkaline hydrolysis of ethyl acetate is essentially an irreversible and second order reaction. Industrial importance of the reaction product, sodium acetate, necessitate for process improvement in terms of maximum conversion and economical usage of raw materials. Statistical design of experiments was utilized to enhance conversion in both batch and plug flow reactors.A full two level factor...

in this paper, we consider the fuzzy fixed-charge transportation problem (ffctp). both of fixed and transportation cost are fuzzy numbers. contrary to previous works, electromagnetism-like algorithms (em) is firstly proposed in this research area to solve the problem. three types of em; original em, revised em, and hybrid em are firstly employed for the given problem. the latter is being firstl...