In k 2 experimental design, the classical fractional factorial designs, the Plackett-Burman designs and the Taguchi orthogonal-array designs all require, with few exceptions, n 2 test conditions, for some k n ≤ . Tsao and Wibowo (2005) pointed out that when only m of the k 2 effects/interactions are non-zero, only m test conditions are required for their estimation. Given the identities of m pr...

This study investigates the effect of some formulation variables on particulate characteristics of poly (DL-lactide-co-glycolide) (PLGA) copolymer nanoparticles by applying 2(3) factorial design and response surface methodology (RSM). Nanoparticles were prepared by solvent displacement technique. Initially, appropriate formulation factors for elaboration of polymeric particles were selected by ...

in this work, the influence of different edm parameters (pulse current, pulse voltage, pulse on-time , pulse off-time) in finishing stage on  the surface roughness (r a )  as a result of application copper electrode to a workpiece( cold work steel  din1.2379)  has been investigated. design of the experiment was chosen as full factorial. statistical analysis has been done and artificial neural n...

Objective: This research aims to optimize the solid lipid nanoparticles by using full factorial design improve delivery of rivastigmine tartrate (RT), which is used for treatment Alzheimer’s disease (AD). Solid (SLNs) are attracting importance drug developers due their performance. The outcome this will lead improvements in release and solubility RT better therapeutic effect. Methods: Four diff...