Transcription of the rat tyrosine hydroxylase (TH) gene is controlled by enhancer sequences in its 5' flanking region; these enhancers include the AP1, dyad, and cAMP response element (CRE) motifs. We show that a novel basal promoter element (-17 GCCTGCCTGGCGA -5) positioned between the TATA box and +1 works in conjunction with the upstream AP1-dyad and CRE enhancers but cannot support transcri...

Transcription factor p63, a p53 family member, plays a role in epithelial cell development, cell cycle arrest, apoptosis, and tumorigenesis. Point mutations, primarily in the DNA binding domain (p63DBD), lead to malformation syndromes. To gain insight into differences between p63 and p53 and the impact of mutations on the structure, we have determined two crystal structures of p63DBD in complex...

A method of comparing two acceleration time histories to determine whether they describe similar physical events is described. The method can be used to assess the repeatability of full-scale crash tests and it can also be used as a criterion for assessing how well a finite-element analysis of a collision event simulates a corresponding full-scale crash test. The method is used to compare a ser...

[1] The responses of karstic aquifers to storms are often used to obtain information about aquifer geometry. In general, spring hydrographs are a function of both system geometry and recharge. However, the majority of prior work on storm pulses through karst has not studied the effect of recharge on spring hydrographs. To examine the relative importance of geometry and recharge, we break karsti...

The derivation of fast, reliable, and accurate modeling procedures for the solution thermal elastohydrodynamic lubrication problems is a topic significant interest in Tribology community. In this paper, novel model order reduction technique introduced analysis problems. method uses static condensation to reduce size linear elasticity part within overall matrix system, followed by splitting algo...