tions in the pattern o f newly synthesized and secreted proteins. There appeared t o be three main modulations under the influence of the fucopolysaccharide. One occurred o n SDS/PAGE in the area o f low molecular mass proteins (below 46 kDa) and two alterations occurred in the area of high molecular mass proteins of 220 kDa and 180 kDa. These two proteins were identified as fibronectin and thr...

Fucoidan is a generic term for a class of fucose rich, structurally diverse sulfated polysaccharides that are found in brown algae and other marine organisms. Depending on the species from which the fucoidan is extracted, a wide variety of biological activities including antitumor, antiinflammatory, immune-modulating, antiviral, antibacterial and proand anticoagulant activities has been describ...

INTRODUCTION Adult bone is continuously remodeled through the formation of new bone tissue by osteoblasts and the resorption of old bone tissue by osteoclasts [1]. In general, an imbalance in bone remodeling that is caused by increased bone resorption over bone formation leads to most adult skeletal diseases including osteoporosis and rheumatoid arthritis [2]. Therefore, the enhanced activation...

Intracellular fucoidanase was isolated from the marine bacterium, Formosa algae strain KMM 3553. The first appearance of fucoidan enzymatic hydrolysis products in a cell-free extract was detected after 4 h of bacterial growth, and maximal fucoidanase activity was observed after 12 h of growth. The fucoidanase displayed maximal activity in a wide range of pH values, from 6.5 to 9.1. The presence...

In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has...

Sulfated polysaccharides, fucoidans, from brown algae are built up mainly of α-L-fucopyranosyl units and form a group of natural biopolymers with a wide spectrum of biological activities. Systematic synthesis of oligosaccharides representing fucoidans' fragments gives molecular probes for detecting pharmacophores within fucoidan polysaccharide chains. Recently, it was discovered that the fucoid...

A large number of studies have suggested that polysaccharides, such as fucoidan and laminarin, in various seaweeds have significant biological properties. A different distribution of molecular weights is a prominent sign of many polysaccharides. Therefore, a simple, fast and reliable high-performance size-exclusion chromatography (HPSEC) method was proposed to separate fucoidan and laminarin fr...

This research was conducted to determine the monosaccharide profile and antioxidant activities of sulphated polysaccharide fucoidan, extracted from Sargassum sp. harvested in Batam, Indonesia. Crude fucoidan (Fsar) using low pH (pH 2) acid method, obtaining a yield 5.5% (w/w), chemical properties Fsar were subsequently compared commercial (Fcomm), obtained Japan. Sulphate contents determined sp...

Fifty male Sprague-Dawley rats were equally divided randomly into five groups to asses the protective and therapeutic effects of fucoidan against diclofenac sodium induced hepatonephrotoxicity. Elevated serum enzyme, increase expression of TLR4, massive hepatic necrosis, fibrosis, calcified mitochondria besides nephritis and coagulative necrosis of renal epithelium were noticed in rats intramus...