DIAPH1 encodes human DIA1, a formin protein that elongates unbranched actin. The c.3634+1G>T DIAPH1 mutation causes autosomal dominant nonsyndromic sensorineural hearing loss, DFNA1, characterized by progressive deafness starting in childhood. The mutation occurs near the C-terminus of the diaphanous autoregulatory domain (DAD) of DIA1, which interacts with its N-terminal diaphanous inhibitory ...

From the days of ARPANET, with slightly over two hundred connected hosts involving five organizations to a massive global, always-on network connecting hosts in the billions, the Internet has become as important as the need for electricity and water. Internet Protocol version 4 (IPv4) could not sustain the growth of the Internet. In ensuring the growth is not stunted, a new protocol, i.e. Inter...

BACKGROUND Most studies measuring substance-use disorders in prisons focus on incoming or on remand prisoners and are generally restricted to drugs. However, there is evidence that substance use initiation or continuation occurs in prison, and that alcohol use is common. The aim of this study is 1) to assess prevalence of both drug and alcohol abuse and dependence (DAD/AAD) in a national random...

Extracts of 16 natural medicine powders (Galla chinensis, Malloti cortex, Cassiae semen, Sophorae radix, Myricae cortex, Crataegi fructus, Gambir, Mume fructus, Geranii herba, Phellodendri cortex, Coptidis rhizoma, Swertiae herba, and Cinnamomi cortex) were assayed for reactive oxygen concentrations using the peroxyoxalate chemiluminescent detection system. High luminescence intensity was obser...

SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) and NCoR (nuclear receptor corepressor) are transcriptional corepressors that play an essential role in the regulation of development and metabolism. This role is achieved, in part, through the recruitment of a key histone deacetylase (HDAC3), which is itself indispensable for cell viability. The assembly of HDAC3 with the ...

word count: 200) Quantification of hemosiderin-laden macrophages in the bronchoalveolar lavage fluid (BALF) has been used to diagnose diffuse alveolar hemorrhage (DAH) but has not been assessed in patients with diffuse alveolar damage (DAD). The current study analyzed BALF obtained in 21 patients with DAD diagnosed by surgical lung biopsy. The median age of 21 patients with DAD was 68 years (ra...

Pulmonary cytomegalovirus (CMV) infection causes fatal CMV pneumonia (CMVp) in immunocompromised patients; however, the mechanisms underlying CMV-infection-induced pulmonary lesion development remain largely unknown. We examined the relationship between CMVp patterns and intrapulmonary viral tropism, including expression of inflammatory cytokines and related molecules. Double immunohistochemist...

Quantification of haemosiderin-laden macrophages in bronchoalveolar lavage fluid (BALF) has been used to diagnose diffuse alveolar haemorrhage (DAH) but has not been assessed in patients with diffuse alveolar damage (DAD). The present study analysed BALF obtained from 21 patients with DAD diagnosed by surgical lung biopsy. The median age of 21 patients with DAD was 68 yrs (range 18-79 yrs); 14 ...

Abstract: In this paper we investigate observability of small solutions of linear differential-algebraic systems with delays (DAD), i.e. solutions that vanish after some finite time. In particular, we prove existence of two kinds of small solutions of DAD systems. The main result are the rank type conditions for observability of three kinds of small solutions of linear differential-algebraic sy...