Furosemide is a sulfonamide-derived diuretic drug which an alternative treatment for heart failure. was made into slow-release tablets to improve the criteria poor furosemide and maximize its absorption in stomach. The purpose of this study determine whether floating with concentration 23% carbopol matrix could meet requirements evaluating physical properties compared theoretically literatur. r...

The type and the amount of binders decisively influence the characteristics of tablets prepared by wet granulation procedure. Commonly used binders like acacia, gelatin, starch and hydrolyzed starch have natural origin. The aim of this study was to evaluate the effectiveness of a new binder extracted from Hibiscus esculentus (Okra gum) in tableting. binder Hibiscus esculentus gum was extracted ...

Arabica coffee (Coffea arabica L.) Java Preanger is the best from West which better known internationally as Preanger. One of secondary metabolites found in beans and efficacious an antioxidant chlorogenic acid. Lozenges were made by wet granulation method with various concentrations extract 5%, 10% 15%. The resulting preparation was then evaluated for its physical activity. Physical evaluation...

Generic drug are identical or bioequivalent to a branded drug in dosage form, safety, strength, route of administration, quality and performance characteristic and intended use. The advantage of generic drug is the low cost because they do not undergo any large expensive clinical trials like other formulations. In 2002 FDA,stated that the Americans saved 56.7 billion dollars and could save addi...

Leucaena (Leucaena leucocephala) seed gum (LSG) was evaluated for disintegrant action in lactose (soluble) based tablets containing ibuprofen, a relatively insoluble drug. The properties of tablets evaluated include weight uniformity, hardness, friability, disintegration time and in vitro dissolution (k, T 50 , A 30 ). LSG, at low concentration level (2% w/w), can be used as a disintegrant in t...

Tizanidine HCl is a centrally acting α-2 adrenergic agonist muscle relaxant. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Tizanidine Hydrochloride using Eudragit E 100 as a taste masking agent. Mass extrusion was the technique used for preparing taste masked granules. The tablet was prepared with three super disint...

The purpose of this article was to prepare and optimize the ingredients of Repaglinide tablets. The impacts of ingredients (diluents, disintegrants and lubricants) content on tablets were evaluated. The optimum prescription contained Repaglinide, meglumine, poloxamer, MCC, maize starch, PVPP, magnesium stearate and appropriate PVP K30.The tablets were evaluated by Carr’s index, hardness, friabi...

The primary objective of this study was to compare the lubrication properties of micronized poloxamer 188 (Lmicrotrol micro 68) and micronized poloxamer 407 (Lmicrotrol micro 127) with certain conventional lubricants such as magnesium stearate and stearic acid. The secondary objective was to use these micronized poloxamers as water-soluble tablet lubricants in preparation of effervecsent tablet...

The purpose of this investigation was to prepare a gastro retentive drug delivery system of famotidine tablets. Floating tablets of famotidine were prepared employing lipid solid dispersion spray drying technique with gelucire 50/13 and compritol 888 along with HPMC K100M, lactose, sodium bicarbonate and citric acid. The floating tablets were evaluated for uniformity of weight, hardness, friabi...