Early growth traits in sheep are economically important. Breeding for these traits has been shown to be problematic using quantitative genetic methods, particularly in native sheep herds. Molecular genetics is useful for sheep breeding. The gene for insulin-like growth factor 1 (IGF1) is one of the important candidate genes known for ovine early growth traits. The aim of this study was to inves...

Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the inhabitants of many regions. Objective: To define the frequency of HLA alleles and haplotypes am...

background ability of athletes in speed or endurance contests somehow is determined by inherited muscle fiber types. one of the important genes involved in sport genetics is actn3 that is located on chromosome 11q13-q14 and encodes α-actinin-3, which belongs to highly conserved family of α-actinin proteins. genetic analysis of α-actinin-3 gene has showed a polymorphism r577x (rs1815739), which ...

background: hla b27 is a sub class of human leukocyte antigen (hla) class i molecule. it was known as the first genetic risk factor associating with ankylosing spondylitis (as). allele frequency of hla-b27 alleles is different across populations. the present study is aimed to investigate the prevalence of hla-b27 in patients referred to danesh clinical laboratory during 2014 to 2015. methods an...

background : we conducted the present study to investigate the frequency of prothrombin g20210a mutation among acute lymphoblastic leukemia patients and healthy individuals from western iran and to detect the possible association between this mutation and the risk of acute lymphoblastic leukemia in our population. methods : the studied groups consisted of 92 children with acute lymphoblastic le...

Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this stud...

the genetic polymorphism of some genes related to meat production in three egyptian sheep breeds (barki, rahmani and osseimi) was studied. the candidate genes were: calpastatin, myostatin, diacylglycerol-acyltransferase1, insulin-like growth factor binding protein-3 and booroola fecundity gene. the technique applied was the restriction fragment length polymorphism for the polymerase chain react...

The aim of the present study was to screen the genotype profile of bovine kappa-casein gene among Frieswal (HF × Sahiwal) crossbred cattle developed in India. A total number of two hundred Frieswal cows were evaluated for HinfI RFLP based genotyping of kappa-casein gene. We observed that only two genotypes (AA and AB) exist among the studied population with the genotype frequency of 0.58 (n=117...