The haemolytic activity of iron-dextran complex is found to be a function of time, temperature, pH, and concentration. The lytic action is enhanced by small amounts of added ferrous sulphate. The lytic action is inhibited by chelating agents such as citrate and sequestrene salts, which bind ionic iron, but not by ferric citrate or ferric sequestrene which do not bind iron. The ionised iron cont...

Infrared data for mono-iron complexes possessing two cis-CO together with Mössbauer data for the enzyme and a model complex support the assignment that the iron centre of the cluster-free hydrogenase Hmd is low-spin Fe(II).

1. Torres JE, Sanchez JL. Disseminated pyogenic granuloma developing after an exfoliative dermatitis. J Am Acad Dermatol 1995;32:280-2. 2. Taira JW, Hill TL, Everett MA. Lobular capillary hemangioma (pyogenic granuloma) with satellitosis. J Am Acad Dermatol 1992;27:297-300. 3. Shah M, Kingston TP, Cotterill JA. Eruptive pyogenic granulomas: A successfully treated patient and review of the liter...

Iron metabolism and superoxide metabolism are clearly interactive, especially under pathological conditions. Each can exacerbate the toxicity of the other. Iron overload may amplify the damaging effects of superoxide overproduction in a very broad spectrum of inflammatory or ischemia-related conditions. Furthermore, chronic oxidative stress may modulate iron uptake and storage, leading to a sel...

This study looks at the effect of oxidant exposure on changes in structural components and functional properties of monkey intestinal brush-border membrane vesicles (BBMV). These membranes were found resistant to iron-dependent lipid peroxidation as judged by measurement of various parameters such as formation of malonaldehyde (MDA) and conjugated diene and depletion of total arachidonic acid, ...

Free radical formation is primarily initiated from metal catalytic centers involving iron and copper. Under certain conditions, free radical reactions can lead to free radical cascades and oxidative stress, which can cause biomolecular, cellular and tissue damage (FRD). The use of natural antioxidants to prevent FRD is in most cases not effective. Many chelators have been shown to inhibit free ...

Iron transport into the CNS is still not completely understood. Using a brain perfusion technique in rats, we have shown a significant brain capillary uptake of circulating transferrin (Tf)-bound and free 59Fe (1 nm) at rates of 136 +/- 26 and 182 +/- 23 microL/g/min, respectively, while their respective transport rates into brain parenchyma were 1.68 +/- 0.56 and 1.52 +/- 0.48 microL/g/min. Re...

OBJECTIVES To compare the effects of wheat flours fortified with NaFeEDTA, FeSO4 and elemental iron (electrolytic iron), in improving iron status in anemic students. METHODS Four hundreds anemic students (11 to 18 years old) were divided into four groups and given wheat flour fortified with different iron fortificants at different concentrations: control group (no added iron); NaFeEDTA group ...

[1] The Gulf of Aqaba, northern Red Sea, is an ideal natural laboratory for studying the impact of atmospheric dry deposition of iron to the ocean surface. We have measured atmospheric iron deposition weekly for 18 months, and dissolved and total dissolvable iron concentrations in the stratified summer (August) and well-mixed winter (March) water column. Concentrations of dissolved and total di...

a series of 3- hydroxypyridin -4-one derivatives (hpos) as bidentate iron (iii) chelating agents were synthesized from 3- hydroxypyran -4-ones (maltol and ethyl maltol) in three steps through protection of hydroxyl group . the protected compounds were then reacted with suitable primary amines to give benzylated pyridinones . finally, the benzyl group was removed by catalytic hydrogenation to pr...